{"id":73094,"date":"2005-09-03T00:00:00","date_gmt":"2005-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/receptores-muscarinicos-y-transduccion-de-senales-a-traves-de-la-fosfolipasa-c-beta-en-corteza-cerebral-humana-postmortem-durante-el-desarrollo-y-envejecimiento-no-patologico\/"},"modified":"2005-09-03T00:00:00","modified_gmt":"2005-09-03T00:00:00","slug":"receptores-muscarinicos-y-transduccion-de-senales-a-traves-de-la-fosfolipasa-c-beta-en-corteza-cerebral-humana-postmortem-durante-el-desarrollo-y-envejecimiento-no-patologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/receptores-muscarinicos-y-transduccion-de-senales-a-traves-de-la-fosfolipasa-c-beta-en-corteza-cerebral-humana-postmortem-durante-el-desarrollo-y-envejecimiento-no-patologico\/","title":{"rendered":"Receptores muscarinicos y transduccion de se\u00f1ales a traves de la fosfolipasa c beta en corteza cerebral humana postmortem durante el desarrollo y envejecimiento no patologico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ruiz De Azua Lopez De Vicu\u00f1a I\u00f1igo <\/strong><\/h2>\n<p>Esta tesis doctoral realiza un completo estudio de la funcionalidad as\u00ed como de los niveles de expresi\u00f3n de los principales componentes del sistema de transducci\u00f3n de se\u00f1ales asociado a fosfoinos\u00edtidos de membrana (receptores muscar\u00ednicos-prote\u00ednas gq\/11-fosfolipasa c) en corteza cerebral humana postmortem a lo largo del desarrollo ontog\u00e9nico (pre- y postnatal) y el envejecimiento \u00abno patol\u00f3gico\u00bb. En el estudio se han empleado diversas t\u00e9cnicas experimentales: ensayos de funcionalidad de la actividad enzim\u00e1tica fosfolipasa c con [3h]- ptdins(4,5)p2, t\u00e9cnicas de inmunodetecci\u00f3n con anticuerpos espec\u00edficos y ensayos de fijaci\u00f3n con radioligandos, todas ellas adecuadas y v\u00e1lidas para lograr los objetivos trazados.  como principales y novedosos hallazgos de dicho estudio se encuentran  que: el receptor muscar\u00ednico m1 se encuentra dimerizado de forma constitutiva mediante la formaci\u00f3n de interacciones de tipo covalente en las regiones extracelulares del receptor en membranas de corteza prefrontal humana adulta; determina cuantitativamente los niveles de subunidades alfa de las prote\u00ednas gq\/11 en membranas de corteza cerebral humana adulta en aproximadamente 800 ng\/mg de prote\u00edna total de membrana, estos niveles de expresi\u00f3n implican que dichas prote\u00ednas suponen un 0.1% del total de prote\u00ednas presentes en membranas, y permiten establecer relaciones estequiom\u00e9tricas entre los componentes receptoriales y tranductores del sistema de transducci\u00f3n de se\u00f1ales analizado con un importante exceso de las prote\u00ednas gq\/11; con respecto al estudio del desarrollo ontog\u00e9nico, se describe una alteraci\u00f3n severa de la hidr\u00f3lisis de fosfoinos\u00edtidos estimulada a trav\u00e9s de receptores muscar\u00ednicos y en los niveles de expresi\u00f3n de los enzimas efectores (las cuatro isoformas de la familia fosfolipasa c-  beta) as\u00ed como de los receptores muscar\u00ednicos (especialmente de los subtipos m1, m3 y m5) a lo largo de dicho desarrollo que podr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Receptores muscarinicos y transduccion de se\u00f1ales a traves de la fosfolipasa c beta en corteza cerebral humana postmortem durante el desarrollo y envejecimiento no patologico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Receptores muscarinicos y transduccion de se\u00f1ales a traves de la fosfolipasa c beta en corteza cerebral humana postmortem durante el desarrollo y envejecimiento no patologico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ruiz De Azua Lopez De Vicu\u00f1a I\u00f1igo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Salles Alvira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: albert Badia sancho <\/li>\n<li>Jes\u00fas Florez beledo (vocal)<\/li>\n<li> Del rio zambrano joaquin (vocal)<\/li>\n<li>Jos\u00e9 Pav\u00eda molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruiz De Azua Lopez De Vicu\u00f1a I\u00f1igo Esta tesis doctoral realiza un completo estudio de la funcionalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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