{"id":73099,"date":"2005-09-03T00:00:00","date_gmt":"2005-09-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-diferenciacion-celular-in-vitro-en-celulas-ht-29-m6-de-cancer-colorrectal\/"},"modified":"2005-09-03T00:00:00","modified_gmt":"2005-09-03T00:00:00","slug":"control-de-la-diferenciacion-celular-in-vitro-en-celulas-ht-29-m6-de-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/control-de-la-diferenciacion-celular-in-vitro-en-celulas-ht-29-m6-de-cancer-colorrectal\/","title":{"rendered":"Control de la diferenciaci\u00f3n celular in vitro en c\u00e9lulas ht-29 m6 de c\u00e1ncer colorrectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mayo De Las Casas Clara De La Caridad <\/strong><\/h2>\n<p>La l\u00ednea celular ht-29 m6 es una l\u00ednea tumoral humana derivada de adenocarcinoma de colon, con capacidad de diferenciaci\u00f3n in vitro hacia un fenotipo mucosecretor, obtenida por selecci\u00f3n con 10-7 m y 10-6 m de metotrexato, en tratamientos sucesivos, de la l\u00ednea parental indiferenciada ht-29 (lesuffleur t, et al, 1990). Nosotros utilizamos esta l\u00ednea celular como modelo para estudiar el proceso de diferenciaci\u00f3n in vitro que ocurre de manera espont\u00e1nea durante el crecimiento hacia confluencia. Los resultados que presentamos en este trabajo aportan evidencias s\u00f3lidas acerca del papel del calcio extracelular como modulador no s\u00f3lo de la epitelializaci\u00f3n, sino tambi\u00e9n del ciclo celular y de la expresi\u00f3n g\u00e9nica durante la diferenciaci\u00f3n in vitro. Aunque puede existir m\u00e1s de un mecanismo por el que el calcio extracelular sea responsable de los efectos observados, los resultados obtenidos son consistentes con el requerimiento de contactos de adhesi\u00f3n para la diferenciaci\u00f3n epitelial. adem\u00e1s, los resultados sugieren que reguladores del ciclo celular, concretamente ciclina d1 y p27, desempe\u00f1an un papel determinante en el control del programa de expresi\u00f3n g\u00e9nica durante la diferenciaci\u00f3n. Este resultado es muy relevante ya que: (1) su funci\u00f3n parece tener lugar de manera general sobre el programa de expresi\u00f3n g\u00e9nica, y (2) al estar estas prote\u00ednas implicadas en la progresi\u00f3n tumoral, su mecanismo de acci\u00f3n emerge como una diana para manipular el fenotipo de diferenciaci\u00f3n celular y con ello la tumorigenicidad. Por otro lado, hemos descubierto que parte del proceso de diferenciaci\u00f3n in vitro es independiente de la formaci\u00f3n de contactos de adhesi\u00f3n y de la epitelializaci\u00f3n, concretamente niveles basales de expresi\u00f3n g\u00e9nica asociada a diferenciaci\u00f3n y la producci\u00f3n de ves\u00edculas de moco. Asimismo, en condiciones de no adherencia celular, las c\u00e9lulas no adquieren capacidad invasiva, lo cual nos est\u00e1 indicando que<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control de la diferenciaci\u00f3n celular in vitro en c\u00e9lulas ht-29 m6 de c\u00e1ncer colorrectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control de la diferenciaci\u00f3n celular in vitro en c\u00e9lulas ht-29 m6 de c\u00e1ncer colorrectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mayo De Las Casas Clara De La Caridad <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Mayol  Girbau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: oriol Bachs valldeneu <\/li>\n<li>albert Abad esteve (vocal)<\/li>\n<li>eduardo Batlle gomez (vocal)<\/li>\n<li>Mar\u00eda  leonor Martins soares david (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mayo De Las Casas Clara De La Caridad La l\u00ednea celular ht-29 m6 es una l\u00ednea tumoral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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