{"id":73143,"date":"2005-11-03T00:00:00","date_gmt":"2005-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/resolucion-y-desimetrizacion-enzimatica-de-compuestos-polifuncionales-preparacion-de-productos-de-interes-biologico\/"},"modified":"2005-11-03T00:00:00","modified_gmt":"2005-11-03T00:00:00","slug":"resolucion-y-desimetrizacion-enzimatica-de-compuestos-polifuncionales-preparacion-de-productos-de-interes-biologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/resolucion-y-desimetrizacion-enzimatica-de-compuestos-polifuncionales-preparacion-de-productos-de-interes-biologico\/","title":{"rendered":"Resoluci\u00f3n y desimetrizaci\u00f3n enzim\u00e1tica de compuestos polifuncionales. preparaci\u00f3n de productos de inter\u00e9s biol\u00f3gico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Lopez Garcia <\/strong><\/h2>\n<p>Se ha demostrado en los \u00faltimos a\u00f1os que el empleo de bioctalizadores en s\u00edntesis org\u00e1nica, constituye una alternativa de extraordinaria importancia a la cat\u00e1lisis qu\u00edmica convencional, especialmente para la preparaci\u00f3n de compuestos enantiom\u00e9ricamente puros.  en esta memoria, estructurada en tres cap\u00edtulos, se ha llevado a cabo la resoluci\u00f3n y desimetrizaci\u00f3n de distintos compuestos difuncionales a trav\u00e9s de reacciones enzim\u00e1ticas de acilaci\u00f3n, amin\u00f3lisis y amon\u00f3lisis. Adem\u00e1s, se describe la aplicaci\u00f3n de algunos de los productos quirales obtenidos en la s\u00edntesis de compuestos de inter\u00e9s biol\u00f3gico.  cap\u00edtulo 1  se desarrolla una s\u00edntesis quimioenzim\u00e1tica altamente eficaz de indanos 1,3-difuncionalizados enantiopuros. Los correspondientes cis y trans aminoalcoholes n-protegidos se resuelven mediante acilaci\u00f3n enzim\u00e1tica utilizando calb como biocatalizador.  con esta metodolog\u00eda se pueden obtener todos los posibles is\u00f3meros de forma enantiopura  y con muy buenos rendimientos. La utilidad de estos compuestos se muestra mediante la preparaci\u00f3n de cis y trans indano-1,3-diaminas ortogonalmente protegidas, a trav\u00e9s de una reacci\u00f3n de mitsunobu. La inversi\u00f3n total de la configuraci\u00f3n durante la reacci\u00f3n de mitsunobu se demuestra mediante la combinaci\u00f3n de t\u00e9cnicas de rmn y modelizaci\u00f3n molecular. La utilidad y versatilidad de la estrategia se pone de manifiesto finalmente con la desprotecci\u00f3n selectiva de cada grupo de amino en condiciones suaves de reacci\u00f3n y con altos rendimientos.  cap\u00edtulo 2  se estudia la desimetrizaci\u00f3n de distintos glutaratos proquirales mediante amin\u00f3lisis y amon\u00f3lisis enzim\u00e1tica, siendo de nuevola calv el biocatalizador m\u00e1s eficaz. Independientemente de la estructura del sustrato, la lipasa muestra preferencia hacia el grupo pro-r del mismo, obteni\u00e9ndose siempre los amido\u00e9stres de configuraci\u00f3n s. En ning\u00fan caso se ha detectado la formaci\u00f3n de diamidas. Sin embar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Resoluci\u00f3n y desimetrizaci\u00f3n enzim\u00e1tica de compuestos polifuncionales. preparaci\u00f3n de productos de inter\u00e9s biol\u00f3gico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Resoluci\u00f3n y desimetrizaci\u00f3n enzim\u00e1tica de compuestos polifuncionales. preparaci\u00f3n de productos de inter\u00e9s biol\u00f3gico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Lopez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Gotor Santamar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Albericio palomera <\/li>\n<li>Fernando Lopez ortiz (vocal)<\/li>\n<li>Santiago vicente Luis lafuente (vocal)<\/li>\n<li>Mar\u00eda  isabel Burguete azcarete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Lopez Garcia Se ha demostrado en los \u00faltimos a\u00f1os que el empleo de bioctalizadores en s\u00edntesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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