{"id":73158,"date":"2005-11-03T00:00:00","date_gmt":"2005-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-secrecion-de-cortisol-por-angiotensina-ii-y-esfingosina-1fosfato-en-celulas-de-fasciculada\/"},"modified":"2005-11-03T00:00:00","modified_gmt":"2005-11-03T00:00:00","slug":"regulacion-de-la-secrecion-de-cortisol-por-angiotensina-ii-y-esfingosina-1fosfato-en-celulas-de-fasciculada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-de-la-secrecion-de-cortisol-por-angiotensina-ii-y-esfingosina-1fosfato-en-celulas-de-fasciculada\/","title":{"rendered":"Regulacion de la secrecion de cortisol por angiotensina ii y esfingosina 1fosfato en celulas de fasciculada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Angeles Rabano Azurmendi <\/strong><\/h2>\n<p>La bios\u00edntesis de glucocorticoides est\u00e1 regulada principalmente por las hormonas acth, adrenalina y  angiotensina-ii (at-ii). Aunque est\u00e1 bien establecido que la activaci\u00f3n de la adenilato ciclasa es un mecanismo com\u00fan a la acci\u00f3n de la acth y de la adrenalina, el mecanismo por el cual la at-ii estimula la secreci\u00f3n de cortisol es menos conocido. En el presente trabajo se ha demostrado que la at-ii regula la secreci\u00f3n de cortisol v\u00eda estimulaci\u00f3n de diferentes rutas de se\u00f1alizaci\u00f3n celular tales como la fosfolipasa d (pld)\/ fosfatidato fosfohidrolasa (pap), las quinasas estimuladas por mit\u00f3genos (mapk) de la familia erk y la fosfatidilinositol 3-quinasa (pi3k) \/ prote\u00edna quinasa b (pkb). Por otra parte, uno de los hallazgos m\u00e1s importantes en esta tesis doctoral ha sido el descubrimiento de un nuevo regulador de la secreci\u00f3n de cortisol: la esfingosina-1-fosfato (sph-1-p). se sabe que este fosfoesfingol\u00edpido es capaz de regular importantes funciones celulares, tales como la apoptosis, la proliferaci\u00f3n, la diferenciaci\u00f3n celular o la angiog\u00e9nesis. En este trabajo hemos demostrado que la sph-1-p es tan potente como la adrenalina en inducir la secreci\u00f3n de cortisol en c\u00e9lulas de fasciculada. Sin embargo, al contrario que la adrenalina y la acth, la sph-1-p no ejerce este efecto v\u00eda estimulaci\u00f3n de la producci\u00f3n de ampc. El mecanismo por el cual la sph-1-p estimula la secreci\u00f3n de cortisol se asemeja m\u00e1s al de la at-ii ya que implica la estimulaci\u00f3n de las actividades pld\/pap, mapk (erk1-2) y pi3-k\/pkb.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la secrecion de cortisol por angiotensina ii y esfingosina 1fosfato en celulas de fasciculada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la secrecion de cortisol por angiotensina ii y esfingosina 1fosfato en celulas de fasciculada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Angeles Rabano Azurmendi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Trueba Conde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Macarulla greoles <\/li>\n<li>bego\u00f1a Ochoa olascoaga (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<li>Luisa fernanda Fanjul rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Angeles Rabano Azurmendi La bios\u00edntesis de glucocorticoides est\u00e1 regulada principalmente por las hormonas acth, adrenalina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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