{"id":73159,"date":"2005-11-03T00:00:00","date_gmt":"2005-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-administracion-exogena-de-il-12-en-un-modelo-murino-de-enfermedad-de-injerto-contra-el-huesped\/"},"modified":"2005-11-03T00:00:00","modified_gmt":"2005-11-03T00:00:00","slug":"efecto-de-la-administracion-exogena-de-il-12-en-un-modelo-murino-de-enfermedad-de-injerto-contra-el-huesped","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-administracion-exogena-de-il-12-en-un-modelo-murino-de-enfermedad-de-injerto-contra-el-huesped\/","title":{"rendered":"Efecto de la administraci\u00f3n ex\u00f3gena de il-12 en un modelo murino de enfermedad de injerto contra el hu\u00e9sped"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca Gallego Valad\u00e9s <\/strong><\/h2>\n<p>Hemos analizado el efecto de la il-12 sobre la enfermedad autoinmune en un modelo murino semialog\u00e9nico de enfermedad cr\u00f3nica de injerto contra el hu\u00e9sped (eichc) inducida en ratones (balb\/c a a\/j) f1 (caf1) inyectados por v\u00eda intraperitoneal con c\u00e9lulas semialog\u00e9nicas de la cepa parental balb\/c.  la il-2 fue administrada 1h antes del transplante de c\u00e9lulas semialog\u00e9nicas siguiendo dos protocolos diferentes de administraci\u00f3n:  a,- inyectado 2ug de rmil-12 (il-12 murina recombinante) por rat\u00f3n antes de la primera inyecci\u00f3n de c\u00e9lulas semialog\u00e9nicas.  b,- inyectado los 2 ug de rmil-12 fraccionada en 5 d\u00edas.  se produjo una respuesta th1 pero no apareci\u00f3 la enfermedad aguda de la eich a pesar de las diferencias en clase i y ii de ant\u00edgenos del complejo mayor de histocompatibilidad (mhc) entre donante y receptor. Cuatro d\u00edas despu\u00e9s de la transferencia de c\u00e9lulas semialog\u00e9nicas, los ratones tratados con rmil-12 mostraron una marcada reducci\u00f3n en el porcentaje de c\u00e9lulas b comparado con animales control caf1 y ratones con eich caf1+balb\/c. Despu\u00e9s de 5-6 meses de seguimiento de la enfermedad, el quimerismo de c\u00e9lulas donantes increment\u00f3 significativamente en bazo (70 +- 31 vs 43 +- 31%) y en timo.  la citometr\u00eda de flujo de esplenocitos demostr\u00f3 que el quimierismo de c\u00e9lulas donante estaba constituido por linfocitos t cd4, t cd8 y b y los porcentajes fueron m\u00e1s elevados en animales inyectados con il-12.  adem\u00e1s, el 100% de linfocitos t cd8 fueron de origen donante en los animales con eich tratados con il-12 y el 50% fueron de origen donante en los animales con eich no tratados. Los resultados demostraron que:  1,- la il-12 probablemente juega un papel en el mecanismo del quimerismo de c\u00e9lulas donantes, probablemente producido por mecanismos mediados por ctl donantes anti-hu\u00e9sped.  2,- no induce la variante aguda de la eich a pesar de las diferencias en clase i y ii de mol\u00e9culas del mhc.  3,- la il-12<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la administraci\u00f3n ex\u00f3gena de il-12 en un modelo murino de enfermedad de injerto contra el hu\u00e9sped<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la administraci\u00f3n ex\u00f3gena de il-12 en un modelo murino de enfermedad de injerto contra el hu\u00e9sped <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca Gallego Valad\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Carmen Gelpi Sabater<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pujol borrell <\/li>\n<li>moises Labrador horrillo (vocal)<\/li>\n<li>elisabet Rosell (vocal)<\/li>\n<li>jaume Martorell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca Gallego Valad\u00e9s Hemos analizado el efecto de la il-12 sobre la enfermedad autoinmune en un modelo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,32218,1737,450,156,1323,2953],"tags":[158879,158878,14018,87326,132800,13791],"class_list":["post-73159","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-formacion-de-anticuerpos","category-inmunologia","category-inmunopatologia","category-patologia","category-patologia-experimental","category-trasplante-de-organos","tag-elisabet-rosell","tag-francisca-gallego-valades","tag-jaume-martorell","tag-m-carmen-gelpi-sabater","tag-moises-labrador-horrillo","tag-ricardo-pujol-borrell"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73159"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73159\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}