{"id":73231,"date":"2018-03-09T23:18:06","date_gmt":"2018-03-09T23:18:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-capacidad-protectora-de-moleculas-recombinantes-de-fasciola-hepatica\/"},"modified":"2018-03-09T23:18:06","modified_gmt":"2018-03-09T23:18:06","slug":"evaluacion-de-la-capacidad-protectora-de-moleculas-recombinantes-de-fasciola-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-de-la-capacidad-protectora-de-moleculas-recombinantes-de-fasciola-hepatica\/","title":{"rendered":"Evaluacion de la capacidad protectora de moleculas recombinantes de fasciola hepatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Casanueva Gomez <\/strong><\/h2>\n<p>Este trabajo plantea disponer de una vacuna efectiva contra la fasciolosis, enfermedad animal y humana causada por el trematodo fasciola hepatica. probamos la utilizaci\u00f3n de prote\u00ednas unidas a \u00e1cidos grasos (fabp) y p\u00e9ptidos recombinantes derivados de estas, en nuevos sistemas de adaptaci\u00f3n-adyuvados, y medimos si aumentan los niveles de protecci\u00f3n obtenidos con anteriores sistemas utilizados.  los pasos que se siguieron en el desarrollo de este trabajo fueron: obtenci\u00f3n y purificaci\u00f3n de mol\u00e9culas recombinantes unidas a \u00e1cidos grasos procedentes de fasciola hepatica; dise\u00f1o y expresi\u00f3n de p\u00e9ptidos reconocidos por linfocitos t derivados de la mol\u00e9cula recombinante fh15; se ensayaron estas mol\u00e9culas con nuevos productos adyuvados incorporando inmunomoduladores no t\u00f3xicos;  posteriormente se realiz\u00f3 una evaluaci\u00f3n de la protecci\u00f3n con diferentes protocolos de inmunizaci\u00f3n e infecci\u00f3n, utilizando distintos modelos experimentales (conejo, cordero y rat\u00f3n); y por \u00faltimo se estudi\u00f3 la respuesta inmunol\u00f3gica desencadenada por la aplicaci\u00f3n de la vacuna analizando su balance th1-th2 y su evoluci\u00f3n a lo largo de los experimentos realizados.  una vez realizados los experimentos, observamos que se obtuvo un alto grado de protecci\u00f3n en conejos inmunizados con fh15, efecto que se potencia al aumentar el intervalo de tiempo entre la vacunaci\u00f3n y la infecci\u00f3n;  los efectos positivos obtenidos en la vacunaci\u00f3n con fh15 en modelo ovino consisten en deficiencias en el desarrollo f\u00edsico y biol\u00f3gico de los vermes, tanto disminuci\u00f3n del tama\u00f1o del par\u00e1sito como retraso en su maduraci\u00f3n y disminuci\u00f3n en el n\u00famero de huevos producidos.  los experimentos utilizando un p\u00e9ptido recombinante derivado de fh15, fusionado con glutation -s- transferasa muestran adecuados niveles de protecci\u00f3n, similares en tres modelos experimentales diferentes. Los altos niveles de igg2a detectados en ratones supervivientes vacunados tanto c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion de la capacidad protectora de moleculas recombinantes de fasciola hepatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion de la capacidad protectora de moleculas recombinantes de fasciola hepatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Casanueva Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Muro \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Martinez fernandez <\/li>\n<li>Antonio Osuna carrillo de albornoz (vocal)<\/li>\n<li>Francisco Royo vazquez (vocal)<\/li>\n<li>vicente Ramajo martin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Casanueva Gomez Este trabajo plantea disponer de una vacuna efectiva contra la fasciolosis, enfermedad animal y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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