{"id":73304,"date":"2018-03-09T23:18:10","date_gmt":"2018-03-09T23:18:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adicion-radicalaria-a-enlaces-cn-sa%c2%adntesis-del-esqueleto-basico-de-la-tetrodotoxina-y-de-derivados-de-alfa-aminoacidos\/"},"modified":"2018-03-09T23:18:10","modified_gmt":"2018-03-09T23:18:10","slug":"adicion-radicalaria-a-enlaces-cn-sa%c2%adntesis-del-esqueleto-basico-de-la-tetrodotoxina-y-de-derivados-de-alfa-aminoacidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/adicion-radicalaria-a-enlaces-cn-sa%c2%adntesis-del-esqueleto-basico-de-la-tetrodotoxina-y-de-derivados-de-alfa-aminoacidos\/","title":{"rendered":"Adici\u00f3n radicalaria a enlaces c=n s\u00edntesis del esqueleto b\u00e1sico de la tetrodotoxina y de derivados de alfa-amino\u00e1cidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Fern\u00e1ndez Gonz\u00e1lez <\/strong><\/h2>\n<p>En esta tesis doctoral se han realizado estudios de adicci\u00f3n de radicales generados fotoqu\u00edmicamente a sistemas c=n. Se ha abordado la adicci\u00f3n tanto en su versi\u00f3n intramolular como en la intermolecular.  1. En su versi\u00f3n intramolecular se han sintetizado intermedios avanzados da tetrodotoxina que pose\u00edan el anillo ciclohex\u00e1nico y el centro cuaternario nitrogenado a partir de derivados glucofuran\u00f3sidos. La etapa clave fue una reacci\u00f3n tandem de adicci\u00f3n y ciclaci\u00f3n 6-sexo sobre el \u00e9ter de ettoxima instalado en posici\u00f3n c3 de los derivados.  2. En su versi\u00f3n intermolucular, cabe destacar el desarrollo de una metodolog\u00eda sencilla y eficiente para la s\u00edntesis asim\u00e9trica de alpha amino\u00e1cidos. la etapa clave fue la adici\u00f3n del radical 1,3-dioxolanilo a n. Acilhidrazonas derivadas del (s)-3-amino-4-bencil-oxazolan-2-ona xeneradas in situ a partir del correspondiente alpha-amino\u00e1cido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adici\u00f3n radicalaria a enlaces c=n s\u00edntesis del esqueleto b\u00e1sico de la tetrodotoxina y de derivados de alfa-amino\u00e1cidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adici\u00f3n radicalaria a enlaces c=n s\u00edntesis del esqueleto b\u00e1sico de la tetrodotoxina y de derivados de alfa-amino\u00e1cidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Fern\u00e1ndez Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Alonso Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Alcaide ala\u00f1on <\/li>\n<li>Rafael Pedrosa saez (vocal)<\/li>\n<li>Alberto Garc\u00eda su\u00e1rez (vocal)<\/li>\n<li>Francisco ram\u00f3n Sarabia Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Fern\u00e1ndez Gonz\u00e1lez En esta tesis doctoral se han realizado estudios de adicci\u00f3n de radicales generados fotoqu\u00edmicamente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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