{"id":73312,"date":"2018-03-09T23:18:10","date_gmt":"2018-03-09T23:18:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-diabetes-experimental-en-respuestas-serotonergicas-a-nivel-cardiovascular-y-renal\/"},"modified":"2018-03-09T23:18:10","modified_gmt":"2018-03-09T23:18:10","slug":"influencia-de-la-diabetes-experimental-en-respuestas-serotonergicas-a-nivel-cardiovascular-y-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-la-diabetes-experimental-en-respuestas-serotonergicas-a-nivel-cardiovascular-y-renal\/","title":{"rendered":"Influencia de la diabetes experimental en respuestas serotonergicas a nivel cardiovascular y renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Garcia Domingo <\/strong><\/h2>\n<p>En este trabajo estudiamos las modificaciones que la diabetes experimental inducida en ratas produce sobre las respuestas seroton\u00e9rgicas a nivel cardiovascular y renal.  para ello se han utilizado ratas wistar macho a las que se indujo una diabetes experimental, bien por inyecci\u00f3n de estreptozotocina o de aloxano, y posteriormente se realizaron experimentos de estimulaci\u00f3n simp\u00e1tica total, estimulaci\u00f3n colin\u00e9rgica o estudios \u00abin vitro\u00bb utilizando t\u00e9cnicas de rt-pcr y ri\u00f1\u00f3n aislado perfundido.  los resultados obtenidos han puesto de manifiesto que:  1.- En hiperglucemia inducida se reproduce la respuesta inhibidora que sobre la neurotransmisi\u00f3n simp\u00e1tica ejerce 5-ht, estando esta inhibici\u00f3n mediada a trav\u00e9s de los receptores 5-ht1a de localizaci\u00f3n presin\u00e1ptica, a diferencia de ratas normogluc\u00e9micas, donde los receptores involucrados eran 5-ht1d mayoritariamente.  2.- La diabetes experimental, induce cambios en las v\u00edas de se\u00f1alizaci\u00f3n implicadas en las repuestas seroton\u00e9rgicas inhibidoras de la transmisi\u00f3n simp\u00e1tica; en ratas normogluc\u00e9micas es la v\u00eda de las ciclooxigenasas la que est\u00e1 implicada en dicha inhibici\u00f3n, mientras que en ratas hipergluc\u00e9mcias es la v\u00eda del no la principal implicada.  3.- En hiperglucemia se observan tanto efectos potenciadores como inhibidores de la bradicardia obtenida bien por estimulaci\u00f3n el\u00e9ctrica o por administraci\u00f3n ex\u00f3gena de ach.. Los efectos potenciadores est\u00e1n mediados por activaci\u00f3n de los receptores 5-ht1a\/1b, y los inhibidores por 5-ht1d.  4.- En ri\u00f1\u00f3n aislado perfundido la vasoconstricci\u00f3n est\u00e1 mediada por los receptores 5-ht2, mientras que las acciones vasodilatadoras se producen a trav\u00e9s de los receptores 5-ht1a\/1b. La diabetes experimental potencia la respuesta vasoconstrictora a concentraciones bajas de 5-ht, pero no modifica las respuestas vasodilatadoras.  5.- Los arnm de los receptores 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2a y 5-ht2b est\u00e1n presentes en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la diabetes experimental en respuestas serotonergicas a nivel cardiovascular y renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la diabetes experimental en respuestas serotonergicas a nivel cardiovascular y renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Garcia Domingo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis San Rom\u00e1n Del Barrio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Lopez novoa <\/li>\n<li>valerie Schini-kerth (vocal)<\/li>\n<li>Jos\u00e9 pedro De la cruz cort\u00e9s (vocal)<\/li>\n<li>cristina Velasco garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Garcia Domingo En este trabajo estudiamos las modificaciones que la diabetes experimental inducida en ratas produce 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