{"id":73327,"date":"2018-03-09T23:18:15","date_gmt":"2018-03-09T23:18:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-como-factores-de-riesgo-en-la-aparicion-y-recurrencia-de-la-trombosis-venosa-y-arterial\/"},"modified":"2018-03-09T23:18:15","modified_gmt":"2018-03-09T23:18:15","slug":"polimorfismos-geneticos-como-factores-de-riesgo-en-la-aparicion-y-recurrencia-de-la-trombosis-venosa-y-arterial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-como-factores-de-riesgo-en-la-aparicion-y-recurrencia-de-la-trombosis-venosa-y-arterial\/","title":{"rendered":"Polimorfismos geneticos como factores de riesgo en la aparicion y recurrencia de la trombosis venosa y arterial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Porras <\/strong><\/h2>\n<p>La enfermedad tromb\u00f3tica es una patolog\u00eda de etiolog\u00eda multifactorial en la que intervienen factores tanto gen\u00e9ticos como ambientales determinadas mutaciones o polimorfismos en los genes que codifican prote\u00ednas de la coagulaci\u00f3n o de la fibrinolisis pueden actuar como factores de riesgo para padecer un episodio de trombosis e incrementar su recurrencia. Un inter\u00e9s creciente lo representa el factor v leiden, la mutaci\u00f3n g20210a del gen de la protrombina (fii g20210a) o la mutaci\u00f3n c677t del gen del metilentetrahidrofolato reductasa (mthfr), que interviene en el metabolismo de la homociste\u00edna. Sin embargo, el papel desempe\u00f1ado por cada uno de ellos y su aplicabilidad pr\u00e1ctica, esta todav\u00eda sometido a debate. Este trabajo pretende analizar el papel desempe\u00f1ado por los polimorfismos factor v leiden, fii g20210a y c677 mthfr junto con los niveles de homociste\u00edna en la aparici\u00f3n y recurrencia de la enfermedad tromb\u00f3tica en nuestra poblaci\u00f3n. Un total de 401 pacientes con trombosis venosa, 249 con trombosis arterial y 549 controles sin antecedentes de trombosis fueron analizados. El defecto trombof\u00edlico m\u00e1s frecuente en nuestra \u00e1rea es el fii g20210a. La presencia de factor v leiden incrementa notablemente el riesgo de enfermedad tromboemb\u00f3lica venosa (etv), mientras que el papel de fii g20210a es moderado. La mutaci\u00f3n c677t de la mthfr constituye un defecto frecuente en nuestro medio, pero no supone un riesgo incrementado de enfermedad tromb\u00f3tica. La recurrencia de etv tras un primer episodio est\u00e1 incrementada en un mismo individuo portador de ambas mutaciones factor v leiden y fii g20210a o ser homocigoto para una de ellas. El defecto heterocigoto aislado no supone un riesgo aumentado de recurrencia. La hiperhomocisteinemia se asocia de forma significativa con la enfermedad tromb\u00f3tica, tanto venosa como arterial y constituye un fuerte predictor de recurrencia tromb\u00f3tica en pacientes tras un primer episodio de enfermedad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos geneticos como factores de riesgo en la aparicion y recurrencia de la trombosis venosa y arterial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos geneticos como factores de riesgo en la aparicion y recurrencia de la trombosis venosa y arterial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Porras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Alberca Silva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Vicente garcia <\/li>\n<li>marcos Gonzalez diaz (vocal)<\/li>\n<li>eduardo Rocha hernando (vocal)<\/li>\n<li>pedro Pab\u00f3n osuna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ram\u00f3n Gonz\u00e1lez Porras La enfermedad tromb\u00f3tica es una patolog\u00eda de etiolog\u00eda multifactorial en la que intervienen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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