{"id":73411,"date":"2005-04-04T00:00:00","date_gmt":"2005-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-geneticos-de-inflamacion-en-la-angina-inestable-estudio-de-los-poliforfismos-308-g-a-y-ser128arg-en-los-genes-tnf-a-y-e-selectina\/"},"modified":"2005-04-04T00:00:00","modified_gmt":"2005-04-04T00:00:00","slug":"marcadores-geneticos-de-inflamacion-en-la-angina-inestable-estudio-de-los-poliforfismos-308-g-a-y-ser128arg-en-los-genes-tnf-a-y-e-selectina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-geneticos-de-inflamacion-en-la-angina-inestable-estudio-de-los-poliforfismos-308-g-a-y-ser128arg-en-los-genes-tnf-a-y-e-selectina\/","title":{"rendered":"Marcadores gen\u00e9ticos de inflamaci\u00f3n en la angina inestable: estudio de los poliforfismos-308 g\/a y ser128arg en los genes tnf-a y e-selectina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ca\u00f1as Pedrosa Ana Mar\u00eda <\/strong><\/h2>\n<p>En nuestra comunidad aut\u00f3noma, as\u00ed como en el resto de espa\u00f1a y paises desarrollados, la enfermedad cardiovascular constituye la principal causa de muerte, por lo que hemos de considerarla como una prioridad sanitaria. El presente trabajo de tesis se encuadra en la l\u00ednea de investigaci\u00f3n de la gen\u00f3mica de la enfermedad cardiovascular. El objetivo del mismo es estudiar en una amplia serie de pacientes diagnosticados de s\u00edndrome coronario agudo (angina inestable) procedentes de las provincias de las palmas y vitoria dos variantes polim\u00f3rficas en dos genes relacionados con la inflamaci\u00f3n (-308 g\/a tnf-a y sert128arg e-selectina). Se analiza si alguno de estos polimorfismos se asocia a una mayor probabilidad de presentar angina inestable y si existen diferencias de distribuci\u00f3n de los mencionados polimorfismos entre la poblaci\u00f3n canaria y alavesa que pudieran explicar la discrepancia de morbimortalidad entre ambas poblaciones (canarias presenta la tasa de mortalidad por enfermedad coronaria m\u00e1s alta de espa\u00f1a y \u00e1lava una de las menores).  los resultados de nuestro estudio reflejan una mayor preValencia de hipercolesterolemia, diabetes, hipertensi\u00f3n y tabaquismo, asi como una menor edad de presentaci\u00f3n de complicaciones de la aterosclerosis coronaria, en los pacientes canarios. Por s\u00ed solos, los genes estudiados no est\u00e1n asociados con el desarrollo de la angina inestable; sin embargo, nuestros resultados reflejan una interacci\u00f3n multiplicativa entre el alelo hiperproductor de tnf-a (alelo -308a) y la diabetes en el riesgo de angina inestable. Esta interacci\u00f3n junto con una mayor frecuencia del alelo -308a tnf-a en gran canaria y la mayor preValencia de diabetes en esta regi\u00f3n podr\u00edan contribuir en parte a la mayor mortalidad por enfermedad coronaria en la comunidad canaria. El genotipo ser128arg e-selectina es un potente predictor independiente de reincidencia del s\u00edndrome coronario agudo y contribuye a caracterizar la var<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores gen\u00e9ticos de inflamaci\u00f3n en la angina inestable: estudio de los poliforfismos-308 g\/a y ser128arg en los genes tnf-a y e-selectina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores gen\u00e9ticos de inflamaci\u00f3n en la angina inestable: estudio de los poliforfismos-308 g\/a y ser128arg en los genes tnf-a y e-selectina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ca\u00f1as Pedrosa Ana Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Rodriguez Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sergio Ruiz santana <\/li>\n<li>domingo Hernandez marrero (vocal)<\/li>\n<li>ruperto Vargas Garc\u00eda (vocal)<\/li>\n<li> Rodr\u00edguez esparrag\u00f3n Francisco Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ca\u00f1as Pedrosa Ana Mar\u00eda En nuestra comunidad aut\u00f3noma, as\u00ed como en el resto de espa\u00f1a y paises [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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