{"id":73412,"date":"2005-04-04T00:00:00","date_gmt":"2005-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-del-anticuerpo-anti-beta-lactoglobulina-en-la-secrecion-de-insulina\/"},"modified":"2005-04-04T00:00:00","modified_gmt":"2005-04-04T00:00:00","slug":"accion-del-anticuerpo-anti-beta-lactoglobulina-en-la-secrecion-de-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-del-anticuerpo-anti-beta-lactoglobulina-en-la-secrecion-de-insulina\/","title":{"rendered":"Accion del anticuerpo anti beta lactoglobulina en la secrecion de insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Beltra Garcia Calvo Marta <\/strong><\/h2>\n<p>Antecedentes: estudios recientes demuestran que el consumo de f\u00f3rmulas l\u00e1cteas en lactantes aumenta el riesgo de padecer diabetes mellitus tipo 1. Adem\u00e1s en el suero de ni\u00f1os recien diagnosticados de diabetes mellitus tipo 1 existen anticuerpos frente a beta-lactoglobulina.  objetivos: estudiar si el anticuerpo anti beta-lactoglobulina puede afectar a la funci\u00f3n de la c\u00e9lula beta de los islotes de langerhans.  material y metodos: islotes de langerhans aislados de humano y de rat\u00f3n se preincubaron 5 horas en presencia de distintas concentraciones de suero de ni\u00f1os diab\u00e9ticos y de celiacos positivos para el anticuerpo  anti beta-lactoglobulinay anticuerpo anti beta-lactoglobulina purificado de estos sueros. En rat\u00f3n tambi\u00e9n se utilizaron suero, inmunoglobulina g y suero anti beta-lactoglobulina de conejo. Mediante radioinmunoensayo se midi\u00f3 la secreci\u00f3n de insulina en respuesta a glucosa. Se realizaron inmunocitoqu\u00edmicas en c\u00e9lulas aisladas de islote de rat\u00f3n y de humano, incubando 2 horas con los sueros y anticuerpos utilizados anteriormente. Tambi\u00e9n se llevaron a cabo estudios de western blot de la fracci\u00f3n citos\u00f3lica  y de membrana de los islotes de langerhans as\u00ed como de otros tejidos.  resultados: la preincubaci\u00f3n de islotes de langerhans de humano y de rat\u00f3n con el suero positivo para beta -lactoglobulina tanto de conejo como de ni\u00f1os diab\u00e9ticos y celiacos , ejerce un efecto inhibitorio sobre la secreci\u00f3n de insulina a 2,75 y 22 mm glucosa. Sin embargo la secreci\u00f3n de insulina de los islotes no se ve afectada cuando se preincuban estos islotes con sueros control (ni\u00f1os sanos) o de conejo (suero preinmune), asi como con inmunoglobulina g de conejo. La inmunocitoqu\u00edmica mostr\u00f3 un marcaje espec\u00edfico para c\u00e9lula beta con el suero positivo al anticuerpo anti beta-lactoglobulina, es decir, el anticuerpo anti beta-lactoglobulina reconoce \u00fanicamente a las c\u00e9lulas productoras de insulina que son las c\u00e9lulas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Accion del anticuerpo anti beta lactoglobulina en la secrecion de insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Accion del anticuerpo anti beta lactoglobulina en la secrecion de insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Beltra Garcia Calvo Marta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Mart\u00edn Bermudo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  del carmen Lopez Martinez <\/li>\n<li>Francisco Bedoya bergua (vocal)<\/li>\n<li>bernat Soria escoms (vocal)<\/li>\n<li>everardo Magalhaes carneiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beltra Garcia Calvo Marta Antecedentes: estudios recientes demuestran que el consumo de f\u00f3rmulas l\u00e1cteas en lactantes aumenta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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