{"id":73432,"date":"2005-06-04T00:00:00","date_gmt":"2005-06-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-de-nuevas-mutaciones-en-componentes-de-la-va%c2%ada-de-la-protea%c2%adna-c-asociadas-con-un-mayor-riesgo-trombotico\/"},"modified":"2005-06-04T00:00:00","modified_gmt":"2005-06-04T00:00:00","slug":"deteccion-de-nuevas-mutaciones-en-componentes-de-la-va%c2%ada-de-la-protea%c2%adna-c-asociadas-con-un-mayor-riesgo-trombotico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/deteccion-de-nuevas-mutaciones-en-componentes-de-la-va%c2%ada-de-la-protea%c2%adna-c-asociadas-con-un-mayor-riesgo-trombotico\/","title":{"rendered":"\u00abdetecci\u00f3n de nuevas mutaciones en componentes de la v\u00edade la prote\u00edna c. asociadas con un mayor riesgo tromb\u00f3tico\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Del Pilar Medina Badenes <\/strong><\/h2>\n<p>El sistema de la prote\u00edna c presenta actividades anticoagulantes, antiinflamatorias, antiapopt\u00f3icas, neuroprotectoras y profibrinol\u00edticas para la activaci\u00f3n de la prote\u00edna c se requiere el precio ensamblaje de, al menos, la trombina. trombomodulina, prote\u00edna c y epcr. As\u00ed, la apc detiene la coagulaci\u00f3n, por ello, cambios en la expresi\u00f3n o en el ensamblaje de estas cuatro prote\u00ednas podr\u00edan dar lugar a una reducci\u00f3n de apc y un aumento del riesgo tromb\u00f3tico. hemos desarrollado un ensayo para cuantificar la apc circulante, mediante el cual hemos observado que un nivel reducido de apc es un factor de riesgo prevalente e independiente de tromboembolismo venoso, el cual parece estar gen\u00e9ticamente determinado. Hemos idetificado humerosas mutaciones en las prote\u00ednas del sistema de activaci\u00f3n de la prote\u00edna c. El poliformismo c1418t (ala 455 val) en la trombomodulina est\u00e1 asociado con niveles elevados de apc y un menor riesgo tromb\u00f3tico. El a4600e (ser219gly) en el epcr, determina los niveles plasm\u00e1ticos de epcr soluble. Y, finalmente, el polimorfismo g4678c en el gen del epcr est\u00e1 asociado con niveles elevados de apc y una disminuci\u00f3n del riesgo tromb\u00f3tico, como ocurre en aquellos portadores de la mutaci\u00f3n protromb\u00f3tica factor v leiden.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abdetecci\u00f3n de nuevas mutaciones en componentes de la v\u00edade la prote\u00edna c. asociadas con un mayor riesgo tromb\u00f3tico\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abdetecci\u00f3n de nuevas mutaciones en componentes de la v\u00edade la prote\u00edna c. asociadas con un mayor riesgo tromb\u00f3tico\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Del Pilar Medina Badenes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Espa\u00f1a Furi\u00f3<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li>edelmiro Reganon salvador (vocal)<\/li>\n<li>enrique Alborch dom\u00ednguez (vocal)<\/li>\n<li>vicente Vicente Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Pilar Medina Badenes El sistema de la prote\u00edna c presenta actividades anticoagulantes, antiinflamatorias, antiapopt\u00f3icas, neuroprotectoras [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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