{"id":73443,"date":"2005-07-04T00:00:00","date_gmt":"2005-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-molecular-del-proceso-inflamatorio-en-la-lesion-pulmonar-aguda\/"},"modified":"2005-07-04T00:00:00","modified_gmt":"2005-07-04T00:00:00","slug":"estudio-molecular-del-proceso-inflamatorio-en-la-lesion-pulmonar-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-molecular-del-proceso-inflamatorio-en-la-lesion-pulmonar-aguda\/","title":{"rendered":"Estudio molecular del proceso inflamatorio en la lesion pulmonar aguda"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Herrera Abreu  Mar\u00eda  Teresa <\/strong><\/h2>\n<p>Estudio de la expresion de citoquinas en el pulm\u00f3n, su liberaci\u00f3n en sangre, y su correlaci\u00f3n con el da\u00f1o pulmonar y la mortalidad en un modelo animal de lesi\u00f3n pulmonar aguda inducida por el respirador. El uso de una estrategia de ventilaci\u00f3n da\u00f1ina (alto volumen corriente) correlaciona con una mayor producci\u00f3n de citoquinas pro-inflamatorias y con un mayor da\u00f1o pulmonar que puede derivar en fibrosis.  a su vez, en un modelo in vitro en fibroblastos analizamos el efecto de la citoquina interleuquina-1 (il-1) sobre la repuesta de los fibroblastos. nos centramos en el estudio de la cascada de activaci\u00f3n de la quinasa regulada por se\u00f1al extracelular (erk) y en su regulaci\u00f3n por medio de los contactos de la c\u00e9lula con la matriz (adhesiones focales, integrinas). Tambi\u00e9n estudiamos la importancia de la fosfatasa shp2 en la cascada de erk inducida por il-1. nuestros resultados mostraron que la fosfatasa shp2 es necesaria para la activaci\u00f3n de erk en las adhesiones focales y para la maduraci\u00f3n de las adhesiones focales en repuesta a la il-1. La activaci\u00f3n de erk influye en la proliferaci\u00f3n, supervivencia y migraci\u00f3n de los fibroblastos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio molecular del proceso inflamatorio en la lesion pulmonar aguda<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio molecular del proceso inflamatorio en la lesion pulmonar aguda <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Herrera Abreu  Mar\u00eda  Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Villar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Siverio jose <\/li>\n<li>Javier Belda nacher (vocal)<\/li>\n<li>Francisco Jos\u00e9 Valladares  parrilla (vocal)<\/li>\n<li>Jes\u00fas Blanco varela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Herrera Abreu Mar\u00eda Teresa Estudio de la expresion de citoquinas en el pulm\u00f3n, su liberaci\u00f3n en sangre, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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