{"id":73466,"date":"2005-08-04T00:00:00","date_gmt":"2005-08-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-derivados-pirrolicos-y-pirazolicos-sa%c2%adntesis-y-evaluacion-biologica-frente-a-oxido-na%c2%adtrico-sintasa\/"},"modified":"2005-08-04T00:00:00","modified_gmt":"2005-08-04T00:00:00","slug":"nuevos-derivados-pirrolicos-y-pirazolicos-sa%c2%adntesis-y-evaluacion-biologica-frente-a-oxido-na%c2%adtrico-sintasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nuevos-derivados-pirrolicos-y-pirazolicos-sa%c2%adntesis-y-evaluacion-biologica-frente-a-oxido-na%c2%adtrico-sintasa\/","title":{"rendered":"Nuevos derivados pirr\u00f3licos y piraz\u00f3licos, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica frente a oxido n\u00edtrico sintasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luisa Carlota L\u00f3pez Cara <\/strong><\/h2>\n<p>La neurodegeneraci\u00f3n y muerte neuronal son aspectos comunes en des\u00f3rdenes neurol\u00f3gicos tales como la enfermedad de alzheimer, el mal de parkinson, la esclerosis lateral amiotr\u00f3fica o la enfermedad de huntington. Entre los mecanismos moleculares propuestos conducentes a la muerte neuronal destaca el aumento de calcio intracelular, particularmente en el caso de la neurotoxicidad medida por glutamato, que conduce a nefastas consecuencias mediante la activaci\u00f3n de protestas intracelulares, lipasa, nucleaasa y activaci\u00f3n de la enzima \u00f3xido nitr\u00edco sintetasa (nos) que cataliza la formaci\u00f3n de \u00f3xido n\u00edtrico (no), tanto en las formas constitutivas (endotelial o el nos y neuronal o nos) como inducible (nos).  actualmente, los antagonistas de los receptos de glutamato est\u00e1n siendo investigados con la esperanza de encontrar agentes terap\u00e9uticos selectivos que ayden a luchar contra la neurodegeneraci\u00f3n. Sin embargo, ya que los mecanismos implicados enla neurotoxicidda actualmente propuestos son muy numerosos e interconectados, se considera esencial el desarrollo de nuevos f\u00e1rmacos que ejercen sus efectos en sitios comunes y cruciales de la complicada cascada neurot\u00f3xica para que manifiestan una neuroprotecci\u00f3n eficaz.  la investigaci\u00f3n y desarrollo de agentes aficaces contra la neurodegeneraci\u00f3n pasa por la s\u00edntesis de nuevos f\u00e1rmacos que interfieran en alg\u00fan punto de la compleja se\u00f1alizaci\u00f3n qu\u00edmica d ela que forma parte la nos, incluyendo la inhibici\u00f3n de la propia enzima que es responsable de la s\u00edntesis de no a partir de l-arginina envarios tipos de c\u00e9lulas.  aunque el no participa en la transmisi\u00f3n sin\u00e1ptica de manera normal, niveles excesivos de no pueden llegar a ser neurot\u00f3xicos. La evidencia m\u00e1s importante de una implicaci\u00f3n de no en toxicidad neuronal viene de la neurotoxicidad glutamat\u00e9rgica, a trav\u00e9s de receptores nmda. Esta toxicidad neuronal tambi\u00e9n puede jugar un papel decisivo en enfermedades neuro<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos derivados pirr\u00f3licos y piraz\u00f3licos, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica frente a oxido n\u00edtrico sintasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos derivados pirr\u00f3licos y piraz\u00f3licos, s\u00edntesis y evaluaci\u00f3n biol\u00f3gica frente a oxido n\u00edtrico sintasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luisa Carlota L\u00f3pez Cara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espinosa \u00fabeda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dario Acu\u00f1a castroviejo <\/li>\n<li>Mar\u00eda  dolors Pujol dilme (vocal)<\/li>\n<li>Juan Nicl\u00f3s guti\u00e9rrez (vocal)<\/li>\n<li>Mar\u00eda  isabel Cadavid torres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luisa Carlota L\u00f3pez Cara La neurodegeneraci\u00f3n y muerte neuronal son aspectos comunes en des\u00f3rdenes neurol\u00f3gicos tales como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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