{"id":73497,"date":"2005-11-04T00:00:00","date_gmt":"2005-11-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-geneticos-en-la-etiologa%c2%ada-de-la-diabetes-tipo-1a\/"},"modified":"2005-11-04T00:00:00","modified_gmt":"2005-11-04T00:00:00","slug":"factores-geneticos-en-la-etiologa%c2%ada-de-la-diabetes-tipo-1a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-geneticos-en-la-etiologa%c2%ada-de-la-diabetes-tipo-1a\/","title":{"rendered":"Factores gen\u00e9ticos en la etiolog\u00eda de la diabetes tipo 1a"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Redondo Velasco M. Jose <\/strong><\/h2>\n<p>El objetivo de este proyecto es estudiar la importancia de los factores gen\u00e9ticos en la etiolog\u00eda de la diabetes tipo la y si \u00e9stos, de forma aislada o en combinaci\u00f3n, permiten predecir esta enfermedad. Con ello, pretendemos identificar individuos en riesgo de diabetes tipo la, antes del inicio de la  destrucci\u00f3n autoirnmune, cuando las estrategias preventivas son m\u00e1s eficaces. por otra parte, el descubrimiento de una alteraci\u00f3n gen\u00e9tica responsable de la autoinmunidad contra las c\u00e9lulas beta ayudar\u00eda a dise\u00f1ar tales intervenciones preventivas. Ambas acciones (identificar sujetos en riesgo y dirigir potenciales estrategias preventivas) son aplicables a individuos sanos y a pacientes posttransplante de islotes, en los que la recurrencia de la autoinmunidad causa a menudo el fracaso del transplante. El m\u00e9todo de trabajo empleado fue el an\u00e1lisis de dos series de gemelos no diab\u00e9ticos de  pacientes con diabetes tipo la. Los estudios de gemelos monocigotos y dicigotos son modelos gen\u00e9ticos que permiten generar hip\u00f3tesis que ser\u00e1n luego analizadas en la poblaci\u00f3n general. Entre las conclusiones de este estudio est\u00e1n: (1) los factores gen\u00e9ticos contribuyen de forma muy importante al desarrollo de la diabetes tipo 1, como demuestran la mayor concordancia para diabetes y para autoanticuerpos en los gemelos monocigotos, comparado con los gemelos dicigotos, y el aumento del riesgo entre aquellos gemelos monocigotos portadores del genotipo de riesgo hla dr3-dqa1*050l-dqb1 *0201\/dr4-dqa1*0301-dqb1*0302; (2) hay datos sugerentes de heterogeneidad gen\u00e9tica en la etiolog\u00eda de la diabetes tipo la, tales como el diferente riesgo y velocidad de concordancia para diabetes entre las parejas de gemelos monocigotos en las que el gemelo \u00edndice desarroll\u00f3 diabetes antes de los 25 a\u00f1os y aquellas en las que 10hizo a edades m\u00e1s avanzadas, (3) los polimorfismos en el gen del receptor de la vitamina d se asocian a diferente riesgo de autoin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores gen\u00e9ticos en la etiolog\u00eda de la diabetes tipo 1a<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores gen\u00e9ticos en la etiolog\u00eda de la diabetes tipo 1a <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Redondo Velasco M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Aniceto Luis Charro Salgado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: r\u00edos Serrano <\/li>\n<li>gonz\u00e1lez Casta\u00f1o (vocal)<\/li>\n<li>s\u00e1nchez Pallardo (vocal)<\/li>\n<li>\u00e1lvarez Campillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Redondo Velasco M. Jose El objetivo de este proyecto es estudiar la importancia de los factores gen\u00e9ticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139],"tags":[159529,6462,159527,159525,159526,159528],"class_list":["post-73497","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","tag-alvarez-campillo","tag-aniceto-luis-charro-salgado","tag-gonzalez-castano","tag-redondo-velasco-m-jose","tag-rios-serrano","tag-sanchez-pallardo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73497"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73497\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}