{"id":73535,"date":"2018-03-09T23:18:26","date_gmt":"2018-03-09T23:18:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-moleculas-generales-de-la-expresion-de-una-genoteca-de-plasmodium-falciparum-y-su-aplicabilidad-al-diagnostico-terapeutico-y-o-proteccion\/"},"modified":"2018-03-09T23:18:26","modified_gmt":"2018-03-09T23:18:26","slug":"caracterizacion-de-moleculas-generales-de-la-expresion-de-una-genoteca-de-plasmodium-falciparum-y-su-aplicabilidad-al-diagnostico-terapeutico-y-o-proteccion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-de-moleculas-generales-de-la-expresion-de-una-genoteca-de-plasmodium-falciparum-y-su-aplicabilidad-al-diagnostico-terapeutico-y-o-proteccion\/","title":{"rendered":"Caracterizaci\u00f3n de mol\u00e9culas generales de  la expresi\u00f3n de una genoteca de plasmodium falciparum y su aplicabilidad al diagn\u00f3stico, terap\u00e9utico y\/o protecci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Mar\u00eda Moyano  Bl\u00e1zquez <\/strong><\/h2>\n<p>Para la realizaci\u00f3n de esta tesis doctoral nos planteamos un objetivo general:  identificaci\u00f3n de nuevos genes de plasmodium  falciparum que  codifican prote\u00ednas antig\u00e9nicas con posible valor  diagn\u00f3stico, protector y\/o terap\u00e9utico.  para llevar a cabo este objetivo se construy\u00f3 una genoteca de expresi\u00f3n a partir de los i estadios eritroc\u00edticos del cion resistente dd2. Dicha genoteca fue cribada con una  mezcla de sueros de pacientes con malaria. todos los insertos de adnc fueron aislados. Donados y secuenciados.  de los 35 ciones aislados,33 ten\u00edan secuenciasque codifica banprote\u00edna santig\u00e9nicas i previamente caracterizadas, el 42% de los dones presentaba similitud con resa (ant\u00edgeno de superficie del eritrocito infectado con el estadio de anillo), 27% con csp (prote\u00edna de superficie del circumesporozo\u00edto), el 9% presentaban homolog\u00eda con; prote\u00ednas de las roptrias, otro 9% presentaron homolog\u00eda con mesa (ant\u00edgeno desuperficie  del eritrocito infectado con el par\u00e1sito maduro) y el 6% ten\u00edan similitud con  hsp (prote\u00edna de choque t\u00e9rmico) y lsa (ant\u00edgeno de superficie del estadio de h\u00edgado). Los dos clones que no presentaban homolog\u00eda fueron denominados #3.5 y #3.11, dichos ciones fueron caracterizados. Estos ciones fueron expresados y se puriticaron las prote\u00ednas recombinantes. Se dise\u00f1aron p\u00e9ptidos en las regiones m\u00e1s antig\u00e9nicas con el  fin de evaluar las propiedades diagn\u00f3sticas de estos p\u00e9ptidos y de las prute\u00ednas  recombinantes mediante elisa. Estas dos prote\u00ednas fueron localizadas celular el intracelularmente mediante inmunofluorescencia indirecta y mediante microscop\u00eda electr\u00f3nica de barrido y.Transmisi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de mol\u00e9culas generales de  la expresi\u00f3n de una genoteca de plasmodium falciparum y su aplicabilidad al diagn\u00f3stico, terap\u00e9utico y\/o protecci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de mol\u00e9culas generales de  la expresi\u00f3n de una genoteca de plasmodium falciparum y su aplicabilidad al diagn\u00f3stico, terap\u00e9utico y\/o protecci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Mar\u00eda Moyano  Bl\u00e1zquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agust\u00edn Benito Llanes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  ramon Martinez fernandez <\/li>\n<li>dolores Gonzalez pacanowska (vocal)<\/li>\n<li>ricardo Molina moreno (vocal)<\/li>\n<li>teresa Garate ormaechea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Mar\u00eda Moyano Bl\u00e1zquez Para la realizaci\u00f3n de esta tesis doctoral nos planteamos un objetivo general: identificaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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