{"id":73549,"date":"2018-03-09T23:18:26","date_gmt":"2018-03-09T23:18:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expressio-de-la-zac1-durant-el-desenvolupament-de-raton-paper-de-la-zac1-en-el-sistema-nervios-central\/"},"modified":"2018-03-09T23:18:26","modified_gmt":"2018-03-09T23:18:26","slug":"expressio-de-la-zac1-durant-el-desenvolupament-de-raton-paper-de-la-zac1-en-el-sistema-nervios-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expressio-de-la-zac1-durant-el-desenvolupament-de-raton-paper-de-la-zac1-en-el-sistema-nervios-central\/","title":{"rendered":"Expressi\u00f3 de la zac1 durant el desenvolupament de rat\u00f3n. paper de la zac1 en el sistema nervi\u00f3s central"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Valente Tony <\/strong><\/h2>\n<p>La tasa de  proliferaci\u00f3n celular resulta de un balance entre varios procesos celulares: mitosis, diferenciaci\u00f3n celular y la muerte celular apopt\u00f3tica. la regulaci\u00f3n de este balance es fundamental durante el desarrollo embrionario, la regeneraci\u00f3n celular y el envejecimiento, as\u00ed como en distintos procesos degenerativos y patol\u00f3gicos. Recientemente, se ha clonado un gen, designado zac1, el cu\u00e1l codifica un actor de transcripci\u00f3n que regula la apoptosis y el paro del ciclo celular, mediante v\u00edas independientes. Se ha determinado que en ratones adultos zac1 se expresa en la gl\u00e1ndula pituitaria, en el cerebro, y en distintos tejidos perif\u00e9ricos, as\u00ed como en el tubo neural de embriones de rat\u00f3n con 9 d\u00edas. Distintos estudios han demostrado que zac1 est\u00e1 implicado en el desarrollo tumoral, en la diabetes mellitus neonatal transitoria, en la activaci\u00f3n y\/o represi\u00f3n de receptores nucleares, en la coactivaci\u00f3n de la v\u00eda apopt\u00f3tica p53\/apaf-1,etc. Sin embrago, su funci\u00f3n en el sistema nervioso central es a\u00fan desconocida.  la presente tesis tiene como objetivo general, determinar el papel de zac1 en el sistema nerviosos central del rat\u00f3n. En este sentido, se determin\u00f3 el patr\u00f3n de expresi\u00f3n e zac1 durante el desarrollo embrionario del neuroectodermo y mesodermo, as\u00ed como, durante la maduraci\u00f3n del sistema nervioso central (mediante t\u00e9cnicas de hibridaci\u00f3n in situ e inmunohistoqu\u00edmicas).  adem\u00e1s, se caracteriz\u00f3 el fenotipo de la poblaciones celulares que expresan zac1 durante el desarrollo. En el desarrollo del  neuroectodermo, los resultados obtenidos muestran que zac1 se expresa en las c\u00e9lulas madre\/progenitorias del sistema nervioso central, tanto en desarrollo cm en el animal adulto (zonas germinativas). Su expresi\u00f3n en c\u00e9lulas diferenciadas se restringe a subpoblaciones neuronales de naturaleza gaba\u00e9rgica y catecolin\u00e9rgica. en el desarrollo del mesodermo, los resultados revelaron que zac1 se expresa dur<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expressi\u00f3 de la zac1 durant el desenvolupament de rat\u00f3n. paper de la zac1 en el sistema nervi\u00f3s central<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expressi\u00f3 de la zac1 durant el desenvolupament de rat\u00f3n. paper de la zac1 en el sistema nervi\u00f3s central <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Valente Tony <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carme Carme Auladell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isabel Fari\u00f1as <\/li>\n<li> Garc\u00eda sanz Jos\u00e9 Antonio (vocal)<\/li>\n<li>ama Planas (vocal)<\/li>\n<li>cristina Pujades (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Valente Tony La tasa de proliferaci\u00f3n celular resulta de un balance entre varios procesos celulares: mitosis, diferenciaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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