{"id":73551,"date":"2018-03-09T23:18:26","date_gmt":"2018-03-09T23:18:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-calcineurina-y-la-pka-en-las-crisis-epilepticas-inducidas-por-microperfusion-de-picrotoxina-y-latrunculina-a-en-el-hipocampo-de-la-rata\/"},"modified":"2018-03-09T23:18:26","modified_gmt":"2018-03-09T23:18:26","slug":"estudio-de-la-calcineurina-y-la-pka-en-las-crisis-epilepticas-inducidas-por-microperfusion-de-picrotoxina-y-latrunculina-a-en-el-hipocampo-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-calcineurina-y-la-pka-en-las-crisis-epilepticas-inducidas-por-microperfusion-de-picrotoxina-y-latrunculina-a-en-el-hipocampo-de-la-rata\/","title":{"rendered":"Estudio de la calcineurina y la pka en las crisis epil\u00e9pticas inducidas por microperfusi\u00f3n de picrotoxina y latrunculina a en el hipocampo de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  V\u00e1zquez L\u00f3pez M. Araceli <\/strong><\/h2>\n<p>En este trabajo se manifiestan las relaciones entre las crisis epil\u00e9pticas inducidas mediante perfusi\u00f3n de picrotoxina o latrunculina a en el hipocampo de la rata, y la actividad de dos enzimas imprescindibles para la regulaci\u00f3n de la plasticidad sin\u00e1ptica y los receptores ionotr\u00f3picos del glutamato: la calcineurina y la prote\u00ed07 kinasa dependiente de camp (pka).  esta implicaci\u00f3n est\u00e1 sustentada en dos tipos de resultados experimentales:  en primer lugar, la actividad de la calcineurina aparece incrementada significativamente en los animales sometidos a crisis epil\u00e9pticas inducidas por latrunculina a.  en segundo lugar, el inhibidor de la calcineurina ascomicina posee actividad antiepil\u00e9ptica frente a las crisis inducidas por picrotoxina. En el caso del inhibidor de la pka h-9 hidrocloruro, se producen algunas modificaciones en el n\u00famero de crisis observadas durante su administraci\u00f3n conjunta con la picrotoxina, aunque la disminuci\u00f3n en el tiempo total de crisis no es significativa, por lo que no puede decirse que se haya observado un efecto anticonvulsivante a las dosis estudiadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la calcineurina y la pka en las crisis epil\u00e9pticas inducidas por microperfusi\u00f3n de picrotoxina y latrunculina a en el hipocampo de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la calcineurina y la pka en las crisis epil\u00e9pticas inducidas por microperfusi\u00f3n de picrotoxina y latrunculina a en el hipocampo de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  V\u00e1zquez L\u00f3pez M. Araceli <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Germ\u00e1n Sierra Paredes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: germ\u00e1n Sierra marcu\u00f1o <\/li>\n<li>Jes\u00fas Paniagua soto (vocal)<\/li>\n<li> Teijeira \u00e1lvarez Jos\u00e9 Manuel (vocal)<\/li>\n<li>Manuel Peleteiro fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de V\u00e1zquez L\u00f3pez M. Araceli En este trabajo se manifiestan las relaciones entre las crisis epil\u00e9pticas inducidas mediante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,977],"tags":[678,159634,68285,98437,18278,159633],"class_list":["post-73551","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-santiago-de-compostela","tag-german-sierra-marcuno","tag-german-sierra-paredes","tag-jesus-paniagua-soto","tag-manuel-peleteiro-fernandez","tag-teijeira-alvarez-jose-manuel","tag-vazquez-lopez-m-araceli"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73551"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73551\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}