{"id":73580,"date":"2018-03-09T23:18:30","date_gmt":"2018-03-09T23:18:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/empleo-de-alfa-hidroxicetonas-derivadas-del-alcanfor-en-reacciones-de-alquilacion-y-de-diels-alder-asimetrica\/"},"modified":"2018-03-09T23:18:30","modified_gmt":"2018-03-09T23:18:30","slug":"empleo-de-alfa-hidroxicetonas-derivadas-del-alcanfor-en-reacciones-de-alquilacion-y-de-diels-alder-asimetrica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/empleo-de-alfa-hidroxicetonas-derivadas-del-alcanfor-en-reacciones-de-alquilacion-y-de-diels-alder-asimetrica\/","title":{"rendered":"Empleo de alfa-hidroxicetonas derivadas del alcanfor en reacciones de alquilaci\u00f3n y de diels-alder asim\u00e9trica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ainara Lecumberri Mun\u00e1rriz <\/strong><\/h2>\n<p>En la presente tesis doctoral se describe el empleo de alfa-hidroxicetonas derivadas del alcanfor en reacciones de alquilaci\u00f3n y de diels-alder asim\u00e9tricas.  as\u00ed, se lleva a cabo por vez primera de manera asim\u00e9trica la conversi\u00f3n de acetileno en compuestos carbonilicos alfa-sustituidos con elevada pureza enentiom\u00e9rica.La alfa-hidroximitilcetona derivada del alcanfor es preparada de manera sencilla utilizando acetileno.La introducci\u00f3n secuencial de dos grupos alquilo y posterior escisi\u00f3n oxidante de los compuestos obtenidos conduce a \u00e1cidos carbox\u00edlicos enantiom\u00e9ricamente puros recuper\u00e1ndose a la vez la fuente de informaci\u00f3n quiral r-(+)-alcanfor.Igualmente el tratamiento de los produrctos de alquilaci\u00f3n derivados del alcanfor cn borano o con reactivos organol\u00edticos y posterior escisi\u00f3n oxidante de los productos dio lugar a aldeh\u00eddos y cetonas respectivamente con excesos ensntiom\u00e9ricos superiores al 96%.  la utilidad de estos sustratos derivados del alcanfor en la reacci\u00f3n de alquilaci\u00f3n due demostrada en la s\u00edntesis del \u00e1cido r-2 propiloctanoico, agente terap\u00e9utico de la enfermedad de alzheimer y de su enanti\u00f3mero.  por otro lado, fueron preparadas alfa-hidroxienonas derivadas del alcanfor para su empleo en reacciones de diels-alder asim\u00e9tricas utilizando como organocatalizadores \u00e1cidos de brosted tales como \u00e1cido trifluoroac\u00e9tico y \u00e1cido trifluorometanosulf\u00f3nico que activaron el filodieno mediante la formaci\u00f3n de puentes de hidr\u00f3geno.Las reacciones de diels-alder utilizando tanto dienos c\u00edclicos como ac\u00edclicos cabe se\u00f1alar que alfa-hidroxienonas beta-sustituidas ocn grupos alquilo o arilo tambi\u00e9n fueron efectivas en la reacci\u00f3n de diels-alder.Los aductos obtenidos fueron transformados en \u00e1cidos carbox\u00edlicos y cetonas \u00f3pticamente puros recuper\u00e1ndose la fuente de informaci\u00f3n quiral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Empleo de alfa-hidroxicetonas derivadas del alcanfor en reacciones de alquilaci\u00f3n y de diels-alder asim\u00e9trica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Empleo de alfa-hidroxicetonas derivadas del alcanfor en reacciones de alquilaci\u00f3n y de diels-alder asim\u00e9trica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ainara Lecumberri Mun\u00e1rriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Castillo Jes\u00fas M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Mouri\u00f1o mosquera <\/li>\n<li> Gamboa landa Jos\u00e9 ignacio (vocal)<\/li>\n<li>pilar Gil ruiz (vocal)<\/li>\n<li>Jos\u00e9 Sep\u00falveda arques (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ainara Lecumberri Mun\u00e1rriz En la presente tesis doctoral se describe el empleo de alfa-hidroxicetonas derivadas del alcanfor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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