{"id":73627,"date":"2018-03-09T23:18:34","date_gmt":"2018-03-09T23:18:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-al-estudio-farmacologico-de-uncaria-tomentosa-willd-dc\/"},"modified":"2018-03-09T23:18:34","modified_gmt":"2018-03-09T23:18:34","slug":"aportacion-al-estudio-farmacologico-de-uncaria-tomentosa-willd-dc","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacognosia\/aportacion-al-estudio-farmacologico-de-uncaria-tomentosa-willd-dc\/","title":{"rendered":"Aportaci\u00f3n al estudio farmacol\u00f3gico de uncaria tomentosa (willd.) dc."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Pardo Mar\u00eda Elena <\/strong><\/h2>\n<p>Uncaria tomentosa (willd.) Dc., Popularmente conocida como \u00abu\u00f1a de gato\u00bb, es una especie que posee una larga historia de uso en medicina tradicional en distintas patolog\u00edas inflamatorias y tumorales.     en los ensayos, fitoqu\u00edmicos realizados, se han detectado cuatro grupos de principios activos bien diferenciados: alcaloides, esteroles y triterpenos, catequinas y quinonas, no estando este \u00faltimo grupo fitoqu\u00edmico descrito en la bibliograf\u00eda consultada.     el estudio realizado de la fracci\u00f3n alcalo\u00eddica obtenida nos permite concluir que esta especie pertenece al quimiotipo rico en alcaloides oxind\u00f3licos pentac\u00edclcios, de los cuales hemos identificado: isopteropodina, pteropodina, mitrfilina e isomitrafilina. De todos ellos, mitrafilina es el componente mayoritario, con una proporci\u00f3n del 87,33 %.     con dicha fracci\u00f3n alcalo\u00eddica fueron realizados ensayos de viabilidad celular sobre leucocitos peritoneales de rata y macr\u00f3fagos peritoneales de rat\u00f3n, mostr\u00e1ndose una escasa toxicidad para estos componentes.     como mecanismo de acci\u00f3n implicado en el efecto antiinflamatorio descrito para esta especie, destacamos que la fracci\u00f3n alcalo\u00eddica de i caria tomentosa produce un efecto inhibidor sobre la actividad del enzima mieloperoxidasa y una inhibici\u00f3n sobre la generaci\u00f3n del mediador \u00f3xido n\u00edtrico; comprob\u00e1ndose la no relaci\u00f3n de estos efectos con la captaci\u00f3n directa de las especies reactivas h2o2 y no, respectivamente.     los ensayos de actividad antitumoral realizados con la fracci\u00f3n alcalo\u00eddica de uncaria tomentosa pusieron de manifiesto su marcada actividad frente a las l\u00edneas celulares glioma gamg, neuroblastoma snk-be (2), leucemia de c\u00e9lulas t be-13 y sarcoma de ewing mhh-es-1, siendo especialmente significativo frente al c\u00e1ncer de mana mt-3. En el caso de la leucemia de c\u00e9lulas b sd-1, no mostr\u00f3 actividad.     finalmente, se pudo concluir que los resultados obtenidos ponen de manifiesto que el uso de la corteza<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaci\u00f3n al estudio farmacol\u00f3gico de uncaria tomentosa (willd.) dc.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaci\u00f3n al estudio farmacol\u00f3gico de uncaria tomentosa (willd.) dc. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Pardo Mar\u00eda Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Sa\u00e9n Rodriguez Mar\u00eda Teresa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: elisa Marhuenda requena <\/li>\n<li>salvador Ma\u00f1ez ali\u00f1o (vocal)<\/li>\n<li>Mar\u00eda  teresa Mitjavila cors (vocal)<\/li>\n<li> Espartero s\u00e1nchez Jos\u00e9 lu\u00eds (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Pardo Mar\u00eda Elena Uncaria tomentosa (willd.) Dc., Popularmente conocida como \u00abu\u00f1a de gato\u00bb, es una especie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[489,10715],"tags":[11334,135015,159775,51079,159776,54206],"class_list":["post-73627","post","type-post","status-publish","format-standard","hentry","category-farmacognosia","category-sevilla","tag-elisa-marhuenda-requena","tag-espartero-sanchez-jose-luis","tag-garcia-pardo-maria-elena","tag-maria-teresa-mitjavila-cors","tag-saen-rodriguez-maria-teresa","tag-salvador-manez-alino"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73627"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73627\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}