{"id":73664,"date":"2018-03-09T23:18:34","date_gmt":"2018-03-09T23:18:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-control-de-la-apoptosis-mediada-por-quimioterapia-en-celulas-de-cancer-de-mama-desarrollo-de-estrategias-anti-tumorales\/"},"modified":"2018-03-09T23:18:34","modified_gmt":"2018-03-09T23:18:34","slug":"mecanismos-de-control-de-la-apoptosis-mediada-por-quimioterapia-en-celulas-de-cancer-de-mama-desarrollo-de-estrategias-anti-tumorales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-control-de-la-apoptosis-mediada-por-quimioterapia-en-celulas-de-cancer-de-mama-desarrollo-de-estrategias-anti-tumorales\/","title":{"rendered":"Mecanismos de control de la apoptosis mediada por quimioterapia en c\u00e9lulas de c\u00e1ncer de mama: desarrollo de estrategias anti-tumorales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Jose Real Luna <\/strong><\/h2>\n<p>La tesis doctoral titulada: mecanismos de control de la apoptosis mediada por quimioterapia en c\u00e9lulas de c\u00e1ncer de mama: desarrollo de nuevas estrategias terap\u00e9uticas se adentra en los mecanismos moleculares de resistencia a quimioterapia en c\u00e9lulas de c\u00e1ncer de mama receptor de estr\u00f3geno negativas. en ella se describen en profundidad los elementos moleculares y la implicaci\u00f3n de dos rutas de supervivencia controladas por los receptores de la familia del egfr: her1oegfr y her2. Ambas prote\u00ednas de membrana controlan diferentes funciones celulares como migraci\u00f3n, diferenciaci\u00f3n proliferaci\u00f3n e inhibici\u00f3n de la apoptosis. Ser\u00e1 esta \u00faltima el punto de encuentro de las dos v\u00edas de transducci\u00f3n de se\u00f1al aqu\u00ed descritas y la regulaci\u00f3n de la transcripci\u00f3n de distintos miembros de la familia bcl-2 los verdaderos protagonistas.  por un lado egfr y her2 mantienen la ruta de supervivencia activada a trav\u00e9s del factor transcripcional stat3 y que controla la expresi\u00f3n de la prote\u00edna antiapopt\u00f3tica bcl-2. Adem\u00e1s, la expresi\u00f3n de esta prote\u00edna protege a las c\u00e9lulas de c\u00e1ncer de mama de la apoptosis inducida por quimioterapia. La inhibici\u00f3n de esta ruta de se\u00f1alizaci\u00f3n empleando inhibidores qu\u00edmicos selectivos de la actividad tirosina quinasa de egfr sensibiliza a las c\u00e9lulas tumuorales al tratamiento quimioter\u00e1pico convencional.  del otro lado de la balanza, estos dos receptores de membrana activan la ruta pi-3k\/akt que mantiene reprimida la expresi\u00f3n de bnip3l, una prote\u00edna facilitadora de la apoptosis (pro-apopt\u00f3tica) de la familia bcl-2. Adem\u00e1s, el bloqueo con anticuerpos monoclonales espec\u00edficos frente a egfr y her2, utilizados actualmente en el tratamiento de distintos tipos de c\u00e1nceres, consigue la inducci\u00f3n de bnip3l que sensibiliza a las c\u00e9lulas de c\u00e1ncer de mama frente a la quimioterapia. Esta misma ruta de se\u00f1alizaci\u00f3n tambi\u00e9n ha sido analizada en muestras tumorales de c\u00e1ncer de mama y se comprueb<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de control de la apoptosis mediada por quimioterapia en c\u00e9lulas de c\u00e1ncer de mama: desarrollo de estrategias anti-tumorales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de control de la apoptosis mediada por quimioterapia en c\u00e9lulas de c\u00e1ncer de mama: desarrollo de estrategias anti-tumorales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Jose Real Luna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Fernandez Luna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Le\u00f3n serrano <\/li>\n<li>Francisco xavier Real arribas (vocal)<\/li>\n<li>abelardo L\u00f3pez rivas (vocal)<\/li>\n<li> Maria dolores delgado villar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Jose Real Luna La tesis doctoral titulada: mecanismos de control de la apoptosis mediada por quimioterapia 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