{"id":73700,"date":"2018-03-09T23:18:38","date_gmt":"2018-03-09T23:18:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cla%c2%adnico-y-morfologico-de-las-neuropata%c2%adas-de-fibra-fina\/"},"modified":"2018-03-09T23:18:38","modified_gmt":"2018-03-09T23:18:38","slug":"estudio-cla%c2%adnico-y-morfologico-de-las-neuropata%c2%adas-de-fibra-fina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-cla%c2%adnico-y-morfologico-de-las-neuropata%c2%adas-de-fibra-fina\/","title":{"rendered":"Estudio cl\u00ednico y morfol\u00f3gico de las neuropat\u00edas de fibra fina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Garc\u00e9s S\u00e1nchez <\/strong><\/h2>\n<p>Introducci\u00f3n.  un grupo de neuropat\u00edas sensitivas se debe a la lesi\u00f3n de la fibra nerviosa de fino calibre ( menor que  6 micras de di\u00e1metro), que incluye a las fibras tipo a delta y c, responsables de la transmisi\u00f3n termoalg\u00e9sica y la funci\u00f3n del sistema nervioso aut\u00f3nomo. Constatar la lesi\u00f3n en este tipo de fibras no siempre es posible, o se obtienen rendimientos diagn\u00f3sticos variables seg\u00fan las t\u00e9cnicas. En la \u00faltima d\u00e9cada se ha desarrollado la biopsia de piel como prueba diagn\u00f3stica que permite analizar el estado de las terminaciones de estas fibras en la epidermis, cuantitativa y cualitativamente.  objetivos.  estudiar enfermos con neuropat\u00eda sensitiva dolorosa aplicando t\u00e9cnicas funcionales (an\u00e1lisis de conducciones nerviosas y cuantificaci\u00f3n de umbrales t\u00e9rmicos y doloroso) y morfol\u00f3gicas (an\u00e1lisis de las fibras nerviosas intraepid\u00e9rmicas). comparar los resultados con los obtenidos en sujetos sanos y determinar el rendimiento diagn\u00f3stico de las diferentes t\u00e9cnicas.  material y m\u00e9todos  serie de 26 pacientes con cl\u00ednica de neuropat\u00eda sensitiva dolorosa (8 diab\u00e9ticos,11 idiop\u00e1ticos y 7 expuestos a t\u00f3xicos) y 11 sujetos sanos. Se miden los umbrales al fr\u00edo y al calor y al dolor evocado por calor, en dos \u00e1reas corporales: cara lateral de pierna (a) y dorso de antepi\u00e9 (b). Se analizan las fibras intraepid\u00e9rmicas (fie) de la biopsia de piel tomada en las mismas \u00e1reas, aplicando t\u00e9cnicas inmunohistoqu\u00edmicas (marcadores neuronal pgp 9.5 y de membrana basal anti-col\u00e1geno iv) se cuantifica la densidad de fie (n\u00famero fie\/mm longitud epidermis) y el porcentaje de \u00e1rea de gl\u00e1ndula sudor\u00edpara (gs) inervada, y se describen las  caracter\u00edsticas cualitativas de la inervaci\u00f3n.  resultados  el grupo de pacientes presenta un aumento de los umbrales t\u00e9rmicos (fr\u00edo y calor) y nociceptivo comparado con los sujetos sanos en ambas \u00e1reas corporales. tanto en la densidad de fie como en el porcentaje<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cl\u00ednico y morfol\u00f3gico de las neuropat\u00edas de fibra fina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednico y morfol\u00f3gico de las neuropat\u00edas de fibra fina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Garc\u00e9s S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jes\u00fas Vilchez Padilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  f Ascaso gimilio <\/li>\n<li>jordi Mat\u00edas-guiu gu\u00eda (vocal)<\/li>\n<li>Jos\u00e9 angel Berciano blanco (vocal)<\/li>\n<li>isabel Illa sendra (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Garc\u00e9s S\u00e1nchez Introducci\u00f3n. un grupo de neuropat\u00edas sensitivas se debe a la lesi\u00f3n de la fibra [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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