{"id":73784,"date":"2018-03-09T23:18:42","date_gmt":"2018-03-09T23:18:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacogenetica-de-polimorfismos-del-sistema-renina-angiotensina-aplicada-al-tratamiento-de-la-hipertension-arterial-esencial\/"},"modified":"2018-03-09T23:18:42","modified_gmt":"2018-03-09T23:18:42","slug":"farmacogenetica-de-polimorfismos-del-sistema-renina-angiotensina-aplicada-al-tratamiento-de-la-hipertension-arterial-esencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/farmacogenetica-de-polimorfismos-del-sistema-renina-angiotensina-aplicada-al-tratamiento-de-la-hipertension-arterial-esencial\/","title":{"rendered":"Farmacogen\u00e9tica de polimorfismos del sistema renina angiotensina aplicada al tratamiento de la hipertensi\u00f3n arterial esencial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1lvaro Mayor Olea <\/strong><\/h2>\n<p>Objetivos: estudiar la implicaci\u00f3n de distintos polimorfismos gen\u00e9ticos del sistemas renina angiotensina (sra):inserci\u00f3n delecci\u00f3n (i\/d)del gen de la enzina conversora de angiotensina (eca),el polimorfismo a1166c del gen del receptor at1 de angiotensima y el polimordismo m235t del gen del angiotensin\u00f3geno, en la elecci\u00f3n del tratamiento farmacol\u00f3gico de la hipertensi\u00f3n arterial (hta).  m\u00e9todo: es un estudio retrospectivo basado en el an\u00e1lisis gen\u00e9tico de 250 pacientes (58% mujeres)tratados en monoterapia (ieca o araii)con la hta controlada a lo largo del tiempo.La respuesta a terapia antihipertensiva fue analizada en base al control de la hta a lo largo del tiempo y de los distintos tratamientos de cada paciente fundamentada en su historia cl\u00ednica y farmacol\u00f3gica.  resultados:con respecto al tratamiento con araii, no se hallaron diferencias estad\u00edsticas significativas en las frecuencias al\u00e9licas no genot\u00edpicas en ninguno de los polimorfismos estudiados.  los pacentes tratados con ieca mostraron diferencias significativas ( p mayor 0,05)en cuanto a la presencia del alelo d del polimorfismo i\/d de eca, siendo \u00e9ste m\u00e1s frecuente en sujetos no respondedores (0,73)frente a respondedores (0,58).Tambi\u00e9n se observan diferencias estad\u00edsticamente significativas en las frecuencias del genotipo ii que resulto ser de 0,21 en respondedores y 0,05 en el grupo de pacientes no respondedores (p mayor 0,05).En cuanto al polimorfismo a1166c y m235t, no se observaron diferencias significativas ante la respuesta a los f\u00e1rmacos.  conclusiones:los polimorfismos a1166c del gen del receptor at1 y  m235t del gen del angiotensin\u00f3geno no son factores predictivos de la respuesta al tratamiento de la hipertensi\u00f3n esencial con araii ni con ieca en monoterapia.La determinaci\u00f3n del genotipo del polimorfismo i\/d de eca ser\u00e1 una herramienta \u00fatil en el futuro a la hora de escoger un tratamiento para la hipertensi\u00f3n esencial, siendo el tratami<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacogen\u00e9tica de polimorfismos del sistema renina angiotensina aplicada al tratamiento de la hipertensi\u00f3n arterial esencial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacogen\u00e9tica de polimorfismos del sistema renina angiotensina aplicada al tratamiento de la hipertensi\u00f3n arterial esencial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1lvaro Mayor Olea <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Armando Reyes Engel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>enrique Perez duarte (vocal)<\/li>\n<li>nieves Fernandez arc\u00e1s (vocal)<\/li>\n<li>cristobal Marchal escalona (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1lvaro Mayor Olea Objetivos: estudiar la implicaci\u00f3n de distintos polimorfismos gen\u00e9ticos del sistemas renina angiotensina (sra):inserci\u00f3n delecci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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