{"id":73862,"date":"2005-06-05T00:00:00","date_gmt":"2005-06-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transferencia-genica-a-progenitores-hematopoyeticos-caninos\/"},"modified":"2005-06-05T00:00:00","modified_gmt":"2005-06-05T00:00:00","slug":"transferencia-genica-a-progenitores-hematopoyeticos-caninos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/transferencia-genica-a-progenitores-hematopoyeticos-caninos\/","title":{"rendered":"Transferencia g\u00e9nica a progenitores hematopoy\u00e9ticos caninos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leticia Gonz\u00e1lez Le\u00f3n <\/strong><\/h2>\n<p>El conocimiento de las bases moleculares de gran n\u00famero de patolog\u00edas hace que las c\u00e9lulas madre sean una diana excelente para la terapia g\u00e9nica. las caracter\u00edsticas de estas c\u00e9lulas aseguran que los genes transferidos a una peque\u00f1a poblaci\u00f3n celular puede corregir el da\u00f1o gen\u00e9tico. Esta siendo un objetivo fundamental para muchos investigadores.  la necesidad de un modelo pre-cl\u00ednico en grandes animales que permita abordar estas terapias ha hecho que se utilice el perro para estos fines dado que posee una diversidad g\u00e9nica comparable a la humana.  sobre la base de estas premisas nos propusimos como objetivo concreto la transferencia g\u00e9nica a una poblaci\u00f3n de precursores hempatopoy\u00e9ticos caninos, de un gen marcador, en nuestro caso el gen que codifica para la prote\u00edna verde fluorescente. Ya que los estudios de transducci\u00f3n de c\u00e9lulas hematopoy\u00e9ticas humanas no est\u00e1n los suficientemente perfeccionados como para su aplicaci\u00f3n en protocolos de terapia g\u00e9nica, por lo que la optimizaci\u00f3n en grandes animales, ser\u00eda de gran utilidad con fines terap\u00e9uticos. Este objetivo global se ha dividido en tres objetivos parciales.  * asilamiento, caracterizaci\u00f3n e identificaci\u00f3n de una poblaci\u00f3n de precursores hematopoy\u00e9ticos caninos.  * evaluaci\u00f3n de la capacidad de la poblaci\u00f3n enriquecida de c\u00e9lulas madre hematopoy\u00e9ticas, para anidar, proliferar y diferenciarse: poniendo una atenci\u00f3n especial en los estudios de funcionalidad de la progenie provenida.  * por \u00faltimo, se optimizaran las condiciones previas y ensayaran diferentes protocolos de transferencia g\u00e9nica hasta conseguir un porcentaje id\u00f3neo de c\u00e9lulas transducidas que nos permita, en posteriores estudios, el seguimiento del quimerismo y el abordaje de patolog\u00edas mediante terapia g\u00e9nica.  se obtuvieron unos resultados que se resumen en las siguientes  conclusiones.  * el anticuerpo 6c9 se une a dos poblaciones claramente diferenciadas, de las que solo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Transferencia g\u00e9nica a progenitores hematopoy\u00e9ticos caninos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Transferencia g\u00e9nica a progenitores hematopoy\u00e9ticos caninos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leticia Gonz\u00e1lez Le\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepci\u00f3n Tejero Orego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>jordi Barquinero ma\u00f1ez (vocal)<\/li>\n<li>Juan  Antonio Bueren roncero (vocal)<\/li>\n<li>pilar Sancho l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leticia Gonz\u00e1lez Le\u00f3n El conocimiento de las bases moleculares de gran n\u00famero de patolog\u00edas hace que las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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