{"id":73897,"date":"2005-09-05T00:00:00","date_gmt":"2005-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-de-agregados-celulares-del-cuerpo-carota%c2%addeo-en-pacientes-con-enfermedad-de-parkinson\/"},"modified":"2005-09-05T00:00:00","modified_gmt":"2005-09-05T00:00:00","slug":"trasplante-de-agregados-celulares-del-cuerpo-carota%c2%addeo-en-pacientes-con-enfermedad-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neurocirugia\/trasplante-de-agregados-celulares-del-cuerpo-carota%c2%addeo-en-pacientes-con-enfermedad-de-parkinson\/","title":{"rendered":"Trasplante de agregados celulares del cuerpo carot\u00eddeo en pacientes con enfermedad de parkinson"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Adolfo M\u00ednguez Castellanos <\/strong><\/h2>\n<p>Introducci\u00f3n. El cuerpo carot\u00eddeo (cc) contiene c\u00e9lulas gl\u00f3micas derivadas de la cresta neural que, adem\u00e1s de sintetizar y liberar dopamina, expresan altos niveles de factor neurotr\u00f3fico derivado de una l\u00ednea celular glial (gdnf). En modelos animales de enfermedad de parkinson (ep), el trasplante de agregados celulares del cc ha demostrado poseer capacidad neurorregenerativa sobre el sistema dopamin\u00e9rgico nigro-estriatal. objetivo. Evaluar la seguridad, eficacia cl\u00ednica y efectos neuroqu\u00edmicos del autotrasplante intraestriatal de agregados celulares del cc en pacientes con ep. metodolog\u00eda. Se han intervenido 13 pacientes con ep y complicaciones motoras. El procedimiento quir\u00fargico se realiz\u00f3 en un tiempo bajo anestesia general y consisti\u00f3 en: extirpaci\u00f3n del cc derecho, preparaci\u00f3n de agregados celulares e implantaci\u00f3n bilateral en el estriado mediante estereotaxia. Los pacientes han sido evaluados prequir\u00fargicamente y cada 3 meses tras el trasplante seg\u00fan las recomendaciones del protocolo capsit-pd, con un seguimiento de 1-3 a\u00f1os. Como variable principal de eficacia cl\u00ednica se ha considerado el cambio porcentual en la sub-escala motora de la escala unificada para la ep (updrs iii) en situaci\u00f3n \u00aboff\u00bb de medicaci\u00f3n, evaluada de forma cegada por un neur\u00f3logo independiente a partir de secuencias de v\u00eddeo enmascaradas y presentadas de forma aleatoria. Las variables secundarias han sido distintas escalas motoras, funcionales y de calidad de vida para la ep, una bater\u00eda de pruebas neuropsicol\u00f3gicas y la dosis de medicaci\u00f3n. Los efectos neuroqu\u00edmicos han sido evaluados en un sub-grupo de 7 pacientes mediante tomograf\u00eda por emisi\u00f3n de positrones (pet) con 18f-dopa prequir\u00fargica y al a\u00f1o del trasplante. resultados. El procedimiento ha sido generalmente bien tolerado, a excepci\u00f3n de una paciente que sufri\u00f3 un infarto cerebral postquir\u00fargico con secuelas motoras. De los 12 pacientes analizados, 10 han experimentado distintos grados de mej<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante de agregados celulares del cuerpo carot\u00eddeo en pacientes con enfermedad de parkinson<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante de agregados celulares del cuerpo carot\u00eddeo en pacientes con enfermedad de parkinson <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Adolfo M\u00ednguez Castellanos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 L\u00f3pez Barneo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Campos mu\u00f1oz <\/li>\n<li>Miguel \u00e1ngel Arr\u00e1ez sanchez (vocal)<\/li>\n<li>Jos\u00e9 angel Berciano blanco (vocal)<\/li>\n<li> Campos arillo v\u00edctor Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Adolfo M\u00ednguez Castellanos Introducci\u00f3n. El cuerpo carot\u00eddeo (cc) contiene c\u00e9lulas gl\u00f3micas derivadas de la cresta neural que, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[392,1880],"tags":[160290,1728,160291,11565,4666,66392],"class_list":["post-73897","post","type-post","status-publish","format-standard","hentry","category-neurocirugia","category-neurologia","tag-adolfo-minguez-castellanos","tag-antonio-campos-munoz","tag-campos-arillo-victor-manuel","tag-jose-angel-berciano-blanco","tag-jose-lopez-barneo","tag-miguel-angel-arraez-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73897"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73897\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}