{"id":73931,"date":"2005-11-05T00:00:00","date_gmt":"2005-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-de-farmacos-antipsicoticos-sobre-el-circuito-corteza-prefrontal-nucleos-del-rafe\/"},"modified":"2005-11-05T00:00:00","modified_gmt":"2005-11-05T00:00:00","slug":"accion-de-farmacos-antipsicoticos-sobre-el-circuito-corteza-prefrontal-nucleos-del-rafe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-de-farmacos-antipsicoticos-sobre-el-circuito-corteza-prefrontal-nucleos-del-rafe\/","title":{"rendered":"Acci\u00f3n de f\u00e1rmacos antipsic\u00f3ticos sobre el circuito corteza prefrontal-n\u00facleos del rafe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Merce Amarg\u00f3s Bosch <\/strong><\/h2>\n<p>La corteza prefrontal (cpf) juega un papel crucial en funciones cerebrales superiores, como la cognici\u00f3n, que est\u00e1n alteradas en pacientes esquizofr\u00e9nicos. las neuronas piramidales de la cpf medial (cpfm) integran aferencias excitatorias del c\u00f3rtex y t\u00e1lamo, y modulatorias de los n\u00facleos amin\u00e9rgicos del cerebro medio: los n\u00facleos del rafe (nr), el locus coeruleus y el \u00e1rea tegmental ventral. A su vez, la cpfm controla la actividad de las neuronas serotonin\u00e9rgicas de los nr. Estudios anteriores del grupo han mostrado que la estimulaci\u00f3n de los receptores prefrontales 5-ht2a o ampa incrementa la frecuencia de descarga de las neuronas piramidales y serotonin\u00e9rgicas, y la liberaci\u00f3n de serotonina (5-ht) en la cpfm. Utilizamos la liberaci\u00f3n de 5-ht (t\u00e9cnicas de microdialisis intracerebral) como una medida indirecta de la actividad piramidal.  en la presente tesis doctoral hemos examinado el papel de los receptores corticales excitatorios e inhibitorios en el circuito cpfm-nr, ya que ambas regiones est\u00e1n implicadas en la esquizofrenia. Dada la similar distribuci\u00f3n laminar de los receptores h-ht2a y alpha1-adren\u00e9rgicos en la cpfm y su acci\u00f3n excitatoria sobre la actividad de las neuronas piramidales, comprobamos ha hip\u00f3tesis que los alpha1-adrenoceptores podr\u00edan modular tambi\u00e9n la liberaci\u00f3n de 5-ht.  los f\u00e1rmacos antipsic\u00f3ticos presentan una elevada afinidad por receptores expresados en neuronas piramidales como los 5-ht2a y los alpha1-adrenoceptores. por esta raz\u00f3n, tambi\u00e9n hemos estudiado los efectos de los antipsic\u00f3ticos, al igual que los de antognistas selectivos para estos receptores, sobre el incremento de 5-ht en la cpfm inducido por 1) la cirazolina (agonista alpha1-adren\u00e9rgico), 2) dpi (agonista sertonin\u00e9rgico 5-ht2a\/2c) y 3) el incremento de la neurotransmisi\u00f3n glutamat\u00e9rgica.  nuestros resultados han mostrado que la estimulaci\u00f3n de los alpha1-adrenoceptores y el incremento de la transmisi\u00f3n glutama<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acci\u00f3n de f\u00e1rmacos antipsic\u00f3ticos sobre el circuito corteza prefrontal-n\u00facleos del rafe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acci\u00f3n de f\u00e1rmacos antipsic\u00f3ticos sobre el circuito corteza prefrontal-n\u00facleos del rafe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Merce Amarg\u00f3s Bosch <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> <\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Pazos Carro <\/li>\n<li>Victor Perez Sola (vocal)<\/li>\n<li>Roser Cortes Colome (vocal)<\/li>\n<li>Josep Saura Mart\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Merce Amarg\u00f3s Bosch La corteza prefrontal (cpf) juega un papel crucial en funciones cerebrales superiores, como la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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