{"id":73933,"date":"2005-11-05T00:00:00","date_gmt":"2005-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevas-aportaciones-a-la-sa%c2%adntesis-de-compuestos-tetraca%c2%adclicos-de-naturaleza-isoquinola%c2%adnica-y-naftoquinonica-512b-dihidro-6h-isoindolo12-aisoquinolin-8-onas-561313a-tetrahidr\/"},"modified":"2005-11-05T00:00:00","modified_gmt":"2005-11-05T00:00:00","slug":"nuevas-aportaciones-a-la-sa%c2%adntesis-de-compuestos-tetraca%c2%adclicos-de-naturaleza-isoquinola%c2%adnica-y-naftoquinonica-512b-dihidro-6h-isoindolo12-aisoquinolin-8-onas-561313a-tetrahidr","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/nuevas-aportaciones-a-la-sa%c2%adntesis-de-compuestos-tetraca%c2%adclicos-de-naturaleza-isoquinola%c2%adnica-y-naftoquinonica-512b-dihidro-6h-isoindolo12-aisoquinolin-8-onas-561313a-tetrahidr\/","title":{"rendered":"Nuevas aportaciones a la s\u00edntesis de compuestos tetrac\u00edclicos de naturaleza isoquinol\u00ednica y naftoquin\u00f3nica: 5,12b-dihidro-6h-isoindolo[1,2-a]isoquinolin-8-onas, 5,6,13,13a-tetrahidroisoquino[3,2-a]isoquinolin-8-onas, 5h-benzo[b]carbazol-6,11-dionas y compuestos relacionados"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Barcia Barcia Jos\u00e9 Carlos <\/strong><\/h2>\n<p>La reacci\u00f3n de diels-alder intramolecular de furanos (daimf) de la n-bencil-n-[2-(2-furil)etil]acrilamida (141b) da lugar est\u00e9reoselectivamente a la mezcla rac\u00e9mica del is\u00f3mero exo del cicloaducto correspondiente, a 4-bencil-4-aza-11-oxatriciclo[6.2.1.01,6]undec-9-en-5-ona (140b). Su aromatizaci\u00f3n permite obtener f\u00e1cilmente y con buen rendimiento a las 2-bencil-1,2,3,4-tetrahidro-1-isoquinolionas (139a).  la reacci\u00f3n de diels-alder intramolecular de furanos (daimf) de la 1-(1-furan-2-il-6,7-dimetoxi-3,4-dihidro-1h-isoquinolin-2-il)propenona (142a) da lugar est\u00e9reoselectivamente a la mezcla rac\u00e9mica del is\u00f3mero exo de las 2,3-dimetoxi-10,12a-epoxi-5,8a,9,10,12a 12b-hexahidro-6h-isoindolo[1,2-a]isoquinolin-8-ona (143a). Su aromatizaci\u00f3n conduce a 2,3-dimetoxi-5,12b-dihidro-6h-isoindolol[1,2-a]isoquinolin-8-ona (6d) con rendimientos moderados.  la reacci\u00f3n de diels-alder intramolecular de furanos (daimf) de la 1-(1-furan-2-ilmetil-6,7-dimetoxi-3,4-dihidro-1h-isoquinolin-2-il)propenona (144a) da lugar est\u00e9reoselectivamente a la mezcla rac\u00e9mica del is\u00f3mero exo de las2,3-dimetoxi-10,12a-epoxi 5,6,8a,9,10,12a,13,13a-ocathidroisoquino[3,2-a]isoquinolin-8-ona (145a). Su aromatizaci\u00f3n conduce a 2,3-dimetoxi-5,6,13,13a-tetrahidroisoquino[3,2-a]isoquinolin-8-ona (11c) f\u00e1cilmente y con buen rendimiento.  se desarroll\u00f3 un nuevo m\u00e9todo de s\u00edntesis de 2-hidroxi-6,7-dimetoxi-3-(2-nitrofenil)-[1,4]naftoquinonas (124h) utilizadas previamente por nuestro grupo para sintetizar 8,9-dimetoxi-5h-benzo[b]carbazol-6,11-dionas (34s).  se desarroll\u00f3 un nuevo m\u00e9todo de s\u00edntesis de \u00e1cidos o acetilbenzoicos (178a), basado en el acoplamiento de heck entre n butilvinil\u00e9ter e o-bromobenzoatos de metilo (65g), que da lugar selectivamente al producto de acoplamiento alfa. La hidr\u00f3lisis de estos enol\u00e9teres da lugar a acetilbenzoatos de metilo (178e), que se hidrolizan f\u00e1cilmente a los \u00e1cidos o-acetilbenzoicos (178a). estos compuestos se aislaron c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevas aportaciones a la s\u00edntesis de compuestos tetrac\u00edclicos de naturaleza isoquinol\u00ednica y naftoquin\u00f3nica: 5,12b-dihidro-6h-isoindolo[1,2-a]isoquinolin-8-onas, 5,6,13,13a-tetrahidroisoquino[3,2-a]isoquinolin-8-onas, 5h-benzo[b]carbazol-6,11-dionas y compuestos relacionados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevas aportaciones a la s\u00edntesis de compuestos tetrac\u00edclicos de naturaleza isoquinol\u00ednica y naftoquin\u00f3nica: 5,12b-dihidro-6h-isoindolo[1,2-a]isoquinolin-8-onas, 5,6,13,13a-tetrahidroisoquino[3,2-a]isoquinolin-8-onas, 5h-benzo[b]carbazol-6,11-dionas y compuestos relacionados <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Barcia Barcia Jos\u00e9 Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Estevez Cabanas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Castedo exposito <\/li>\n<li>paul Jenkins (vocal)<\/li>\n<li>angel Gutierrez ravelo (vocal)<\/li>\n<li> Molina orden Mar\u00eda teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Barcia Barcia Jos\u00e9 Carlos La reacci\u00f3n de diels-alder intramolecular de furanos (daimf) de la n-bencil-n-[2-(2-furil)etil]acrilamida (141b) da [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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