{"id":73945,"date":"2005-12-05T00:00:00","date_gmt":"2005-12-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-en-hipertension-arterial-refractaria\/"},"modified":"2005-12-05T00:00:00","modified_gmt":"2005-12-05T00:00:00","slug":"polimorfismos-geneticos-en-hipertension-arterial-refractaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-en-hipertension-arterial-refractaria\/","title":{"rendered":"Polimorfismos geneticos en hipertension arterial refractaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Cruz Gonzalez <\/strong><\/h2>\n<p>La hipertensi\u00f3n arterial refractaria (hta-r) se define como aquellas situaciones en las que no es posible alcanzar el objetivo de presi\u00f3n arterial en pacientes que han realizado modificaciones en el estilo de vida y est\u00e1n tomando las dosis adecuadas de una terapia farmacol\u00f3gica de 3 medicamentos incluyendo un diur\u00e9tico. Hasta el momento esta entidad ha sido abordada como una falta de cumplimiento o mala praxis, sin embargo parte de esta resistencia podr\u00eda determinarse a nivel gen\u00e9tico  estudiamos en 50 pacientes hta-r, 234 hipertensos controlados y 112 sujetos sin hipertensi\u00f3n los polimorfismos gen\u00e9ticos -786c mayor que t nos3, 984g mayor que t, 35g mayor que c pparg, 8473c mayor que t ptgs2, 825c mayor que t gnb, 1947g mayor que a comt, gstm1, gstt1, 313a mayor que g gstp1.  encontramos diferencias entre hta-r e hipertensos controlados, el alelo c de -786c mayor que t nos3 es m\u00e1s frecuente en hta-r con respecto a los controlados (p = 0,014 or 2,32 (1,17-4,63)), el alelo t de 825c mayor que t gnb3 se asocia a hipertensi\u00f3n con respecto a sujetos control (p = 0,016 or 1,4 (1,04-1.91)), y a hipertensi\u00f3n controlado con respecto a hta-r (p = 0,035 or 0.6 (0.38-0.96), el alelo nulo de gstm  aumenta la susceptibilidad de desarrollar hta-r con respecto a hipertensi\u00f3n controlada  (p = 0,025 or 2,029 (1,08-3,78)), y la presencia de gstt se relaciona con hipertensi\u00f3n con respecto a los controles (p = 0,040 or= 1,68 (1,021-2,77))  por tanto existen diferencias en la distribuci\u00f3n de los genotipos de los genes seleccionados en este trabajo entre pacientes con hipertensi\u00f3n arterial refractaria, hipertensi\u00f3n controlada y sujetos no hipertensos, lo que sugiere que el origen de la hipertensi\u00f3n arterial y su respuesta al tratamiento se encuentran, al menos en parte, condicionadas a nivel gen\u00e9tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos geneticos en hipertension arterial refractaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos geneticos en hipertension arterial refractaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Cruz Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lopez de letona Juan <\/li>\n<li>Jos\u00e9 Miguel Lopez novoa (vocal)<\/li>\n<li> Ferreira montero ignacio j. (vocal)<\/li>\n<li>Jos\u00e9 ram\u00f3n Gonz\u00e1lez Juan atey (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Cruz Gonzalez La hipertensi\u00f3n arterial refractaria (hta-r) se define como aquellas situaciones en las que no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,156,1601,9386],"tags":[3110,160368,5695,21301,151090,26315],"class_list":["post-73945","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-patologia","category-patologia-cardiovascular","category-salamanca","tag-ferreira-montero-ignacio-j","tag-ignacio-cruz-gonzalez","tag-jose-miguel-lopez-novoa","tag-jose-ramon-gonzalez-juan-atey","tag-lopez-de-letona-juan","tag-rogelio-gonzalez-sarmiento"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73945"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73945\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}