{"id":7395,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/analisis-de-la-actividad-citolitica-natural-y-las-subpoblaciones-linfocitarias-en-las-leucemias-agudas-efecto-in-vitro-e-in-vivo-de-la-interleucina-2\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"analisis-de-la-actividad-citolitica-natural-y-las-subpoblaciones-linfocitarias-en-las-leucemias-agudas-efecto-in-vitro-e-in-vivo-de-la-interleucina-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-la-actividad-citolitica-natural-y-las-subpoblaciones-linfocitarias-en-las-leucemias-agudas-efecto-in-vitro-e-in-vivo-de-la-interleucina-2\/","title":{"rendered":"Analisis de la actividad citolitica natural y las subpoblaciones linfocitarias en las leucemias agudas: efecto in vitro e in vivo de la interleucina-2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Parrado Gonzalez <\/strong><\/h2>\n<p>Se evaluan, en enfermos de leucemia aguda en distintas fases de tratamiento, el grado de inmunocompetencia \u00abnatural killer\u00bb (nk), la reactividad inmunitaria frente a su propio tumor y el efecto que la interleucina-2 (il-2) produce in vitro (actividad lak), mediante ensayo de citotoxicidad de linfocitos aislados de la sangre periferica de estos enfermos en cocultivo con celulas diana k562, raji y blastos cancerosos autologos. Se caracterizan con anticuerpos monoclonales las poblaciones linfocitarias que se correlacionan con las actividades nk y lak, mediante citometria de flujo. Se realiza un seguimiento longitudinal (2 a\u00f1os) de la recuperacion de las poblaciones linfocitarias despues de trasplante autologo de medula osea (tamo). Se realiza ensayo clinico de tratamiento con il-2 intravenosa en enfermos en post-tamo (n=5), en los que se cuantifican las variaciones producidas en los anteriores parametros como consecuencia del tratamiento. Se valora el cultivo con il-2 de la medula osea como posible intervencion terapeutica ex vivo previa al tamo. Nuestros resultados apoyan la inmunoterapia con il-2 en enfermos con leucemia aguda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de la actividad citolitica natural y las subpoblaciones linfocitarias en las leucemias agudas: efecto in vitro e in vivo de la interleucina-2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de la actividad citolitica natural y las subpoblaciones linfocitarias en las leucemias agudas: efecto in vitro e in vivo de la interleucina-2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Parrado Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez Fernandez Juan  Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Raimundo Goberna Ortiz <\/li>\n<li>Rafael Solana Lara (vocal)<\/li>\n<li>Gregorio Garc\u00eda Herdugo (vocal)<\/li>\n<li>Felix L\u00f3pez Elorza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Parrado Gonzalez Se evaluan, en enfermos de leucemia aguda en distintas fases de tratamiento, el grado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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