{"id":73964,"date":"2018-03-09T23:18:53","date_gmt":"2018-03-09T23:18:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-clinicopatologicas-de-la-expresion-de-proteina-p53-en-los-tumores-uroteliales-de-vejiga\/"},"modified":"2018-03-09T23:18:53","modified_gmt":"2018-03-09T23:18:53","slug":"implicaciones-clinicopatologicas-de-la-expresion-de-proteina-p53-en-los-tumores-uroteliales-de-vejiga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-clinicopatologicas-de-la-expresion-de-proteina-p53-en-los-tumores-uroteliales-de-vejiga\/","title":{"rendered":"Implicaciones clinicopatologicas de la expresi\u00f3n de proteina p53 en los tumores uroteliales de vejiga"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodr\u00edguez Sierra M. Angeles <\/strong><\/h2>\n<p>El carcinoma urotelial de vejiga presenta altas tasas de morbimortalidad, debidas principalmente a la frecuente progresi\u00f3n y recidiva observada a pesar del amplio aspectro terap\u00e9utico que puede ser aplicado. Por esta raz\u00f3n se hace necesaria la adopci\u00f3n de medidas adicionales para mejorar la elecci\u00f3n terap\u00e9utica. La prote\u00edna p53 es un biomarcador relacionado con la g\u00e9nesis, progresi\u00f3n tumoral, y control de la apotosis; por lo que hemos considerado que el estudio de su expresi\u00f3n pudiera detectar grupos de riesgo de progresi\u00f3n y recidiva, as\u00ed como la respuesta terape\u00fatica en la v\u00eda de activaci\u00f3n de la apoptosis.  hemos estudiado 225 pacientes, con un seguimiento m\u00ednimo de tres a\u00f1os; encontrando que la expresi\u00f3n de p53 se ha mostrado como factor predictivo independiente de reciediva y progresi\u00f3n en el an\u00e1lisis multivariante; dependiendo del estadio en el aspecto de supervivencia.  en el an\u00e1lisis factorial de tumores que infiltran la l\u00e1mina propia, hemos encontrado altos porcentajes de pacientes libres de enfermedad en tumores sin sobreexpresi\u00f3n, con similiar eficacia para cualquier tratamiento aplicado a tres a\u00f1os, siendo m\u00e1s efectivo a cinco a\u00f1os la radioterapia. En tumores con sobreexpresi\u00f3n el tratamiento m\u00e1s eficaz ha sido a tres y cinco a\u00f1os la cistectom\u00eda parcial; mostr\u00e1ndose labcg como alternativa a corto plazo, siendo muy bajos los porcentajes de pacientes libres de enfermedad con las dem\u00e1s medidas terape\u00faticas aplicadas.  estos resultados nos sugieren que la valoraci\u00f3n de la expresi\u00f3n de p53 puede ser una herramienta \u00fatil en el manejo del paciente con carcinoma uroterial de vejiga, y deber\u00eda ser incluida en los protocolos de actuaci\u00f3n terap\u00e9utica.  palabras clave: tratamiento, pron\u00f3stico, an\u00e1lisis factorial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones clinicopatologicas de la expresi\u00f3n de proteina p53 en los tumores uroteliales de vejiga<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones clinicopatologicas de la expresi\u00f3n de proteina p53 en los tumores uroteliales de vejiga <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodr\u00edguez Sierra M. Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Coca Menchero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Vaquero crespo <\/li>\n<li> Oya otero Santiago de (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodr\u00edguez Sierra M. Angeles El carcinoma urotelial de vejiga presenta altas tasas de morbimortalidad, debidas principalmente a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957],"tags":[4964,160407,160406,4965],"class_list":["post-73964","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","tag-jesus-vaquero-crespo","tag-oya-otero-santiago-de","tag-rodriguez-sierra-m-angeles","tag-santiago-coca-menchero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=73964"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/73964\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=73964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=73964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=73964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}