{"id":73967,"date":"2018-03-09T23:18:53","date_gmt":"2018-03-09T23:18:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-amplificacion-y-expresion-del-gen-her-2-neu-en-carcinoma-de-prostata-mecanismos-de-accion-relacion-con-variables-clinicopatologicas-y-valor-pronostico\/"},"modified":"2018-03-09T23:18:53","modified_gmt":"2018-03-09T23:18:53","slug":"evaluacion-de-la-amplificacion-y-expresion-del-gen-her-2-neu-en-carcinoma-de-prostata-mecanismos-de-accion-relacion-con-variables-clinicopatologicas-y-valor-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-de-la-amplificacion-y-expresion-del-gen-her-2-neu-en-carcinoma-de-prostata-mecanismos-de-accion-relacion-con-variables-clinicopatologicas-y-valor-pronostico\/","title":{"rendered":"Evaluacion de la amplificacion y expresion del gen her-2\/neu en carcinoma de prostata. mecanismos de accion, relacion con variables clinicopatologicas y valor pronostico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Antunez Plaza <\/strong><\/h2>\n<p>Antecedentes: existe un inter\u00e9s creciente en la prote\u00edna her-2 como factor pron\u00f3stico y como diana terap\u00e9utica en diferentes tipos de c\u00e1ncer, entre ellos el carcinoma de pr\u00f3stata (cp), en el que se postula un papel en la evoluci\u00f3n a estadios avanzados, y en el desarrollo de hormono-independencia.  material y m\u00e9todos: estudiamos 115 pacientes con cp tratados con prostatectom\u00eda radical. De ellos, el 32% hab\u00edan recibido bloqueo hormonal (bh) previo a cirug\u00eda. Se analiz\u00f3 la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna her-2 y se estudio la amplificaci\u00f3n del gen mediante fish. Para ello utilizamos la  t\u00e9cnica de matrices tisulares. Posteriormente buscamos relaciones entre el estado de la prote\u00edna y el gen, variables clinicopatol\u00f3gicas y la expresi\u00f3n de otras prote\u00ednas, entre ellas ki-67 y reguladores del ciclo celular.  resultados y conclusiones: la prote\u00edna her-2\/neu se expresa de forma poco frecuente en cp no tratados; sin embargo, el bh induce su expresi\u00f3n de forma significativa (p=0,002). La expresi\u00f3n de her-2 en el cp se relaciona con el score de gleason, pero no con otras variables clinicopatol\u00f3gicas con valor pron\u00f3stico ni con la supervivencia. Por ello no es una prote\u00edna adecuada valorar la agresividad tumoral o la  evoluci\u00f3n cl\u00ednica de la enfermedad. en el cp la expresi\u00f3n de her-2  se correlaciona significativamente con la expresi\u00f3n de p21 y ciclina d3. La amplificaci\u00f3n del gen her-2\/neu es excepcional en el cp, en el que las ganancias del gen se deben a tri o tetrasom\u00edas del cromosoma 17. La presencia de aneusom\u00eda del cromosoma 17 en carcinoma de pr\u00f3stata se asocia al grado tumoral. Los cp con patrones complejos del cromosoma 17, en particular trisom\u00edas y tetrasom\u00edas muestran una menor respuesta al bh, medida en t\u00e9rminos de cambio involutivo (p=0,038).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion de la amplificacion y expresion del gen her-2\/neu en carcinoma de prostata. mecanismos de accion, relacion con variables clinicopatologicas y valor pronostico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion de la amplificacion y expresion del gen her-2\/neu en carcinoma de prostata. mecanismos de accion, relacion con variables clinicopatologicas y valor pronostico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Antunez Plaza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Mu\u00f1oz Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Herrero zapatero <\/li>\n<li>Juan Silva abuin (vocal)<\/li>\n<li> Alonso martin Mar\u00eda  Jos\u00e9 (vocal)<\/li>\n<li>teresa Flores corral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Antunez Plaza Antecedentes: existe un inter\u00e9s creciente en la prote\u00edna her-2 como factor pron\u00f3stico y como 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