{"id":7399,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/efecto-farmacologico-de-tetrazepam-sobre-musculatura-lisa\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"efecto-farmacologico-de-tetrazepam-sobre-musculatura-lisa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-farmacologico-de-tetrazepam-sobre-musculatura-lisa\/","title":{"rendered":"Efecto farmacologico de tetrazepam sobre musculatura lisa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concepcion Perez Guerrero <\/strong><\/h2>\n<p>Tetrazepam (tzp) es una 1,4-benzodiazepina (bzd) usada en espa\u00f1a (myolastan), con un efecto selectivo que produce miorrelajacion en dosis menores que las que causan ansiolisis o induccion al sue\u00f1o y con una reducida capacidad para provocar dependencia fisica. Esta especificidad supone una gran ventaja frente a otras bzds lo cual le hace ser un farmaco de eleccion en el tratamiento de sindromes musculares espasticos. A pesar de dicha aceptacion, aun no se conoce con exactitud el mecanismo de accion que le confiere dicha especificidad farmacologica y no existen referencias a cerca de su accion sobre organos perifericos de musculatura lisa. Por ello, en esta tesis se aborda ese estudio, sometiendo el farmaco a un estudio farmacologico que nos permita disponer de una informacion mas detallada y precisa sobre su perfil farmacodinamico, analizando su posible interaccion con ciertos receptores especificos, asi como el rango de concentraciones en que es activo, ensayando su efecto sobre organos de musculatura lisa no vascular (duodeno de rata, ileon de cobaya, conductos deferentes de rata, traquea de rata y cobaya, utero de rata) y musculatura lisa vascular (aorta de rata y conejo). De los resultados obtenidos se concluye que tzp ejerce un efecto relajante sobre organos de musculatura lisa, previamente contraidos con distintos agonistas, mostrando un comportamiento de antagonista no competitivo frente a acetilcolina, asi como antagonista de canales de calcio, no mostrando actividad sobre los receptores alfa o beta-adrenergicos ni sobre el histaminergico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto farmacologico de tetrazepam sobre musculatura lisa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto farmacologico de tetrazepam sobre musculatura lisa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concepcion Perez Guerrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Marhuenda Requena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Bravo Diaz <\/li>\n<li> Garcia Gimenez M. Dolores (vocal)<\/li>\n<li> Vitorica Fernandez Francisco J. (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concepcion Perez Guerrero Tetrazepam (tzp) es una 1,4-benzodiazepina (bzd) usada en espa\u00f1a (myolastan), con un efecto selectivo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,957,10715],"tags":[26695,11334,26696,22802,26697],"class_list":["post-7399","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-sevilla","tag-concepcion-perez-guerrero","tag-elisa-marhuenda-requena","tag-garcia-gimenez-m-dolores","tag-luis-bravo-diaz","tag-vitorica-fernandez-francisco-j"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7399"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7399\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}