{"id":74000,"date":"2018-03-09T23:18:57","date_gmt":"2018-03-09T23:18:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-farmacocinetica-de-lopina-vii2-ritonavir-en-pacientes-infectados-por-el-virus-de-la-inmunodeficiencia-humana-con-insuficiencia-hepatica-leve-o-moderada\/"},"modified":"2018-03-09T23:18:57","modified_gmt":"2018-03-09T23:18:57","slug":"estudio-de-la-farmacocinetica-de-lopina-vii2-ritonavir-en-pacientes-infectados-por-el-virus-de-la-inmunodeficiencia-humana-con-insuficiencia-hepatica-leve-o-moderada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-farmacocinetica-de-lopina-vii2-ritonavir-en-pacientes-infectados-por-el-virus-de-la-inmunodeficiencia-humana-con-insuficiencia-hepatica-leve-o-moderada\/","title":{"rendered":"Estudio de la farmacocin\u00e9tica de lopina vii2\/ritonavir en pacientes infectados por el virus de la inmunodeficiencia humana con insuficiencia hep\u00e1tica leve o moderada"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concepci\u00f3n Cepeda Conz\u00e1lez <\/strong><\/h2>\n<p>En los pacientes infectados por el vih de nuestro medio, la preValencia de coinfecci\u00f3n con el vhc es mayor del 70%, y de \u00e9stos, la posibilidad de desarrollar insuficiencia hep\u00e1tica es superior al 50%. Lopinavir\/ritonavir es un antirretroviral fundamental en el tratamiento de la infecci\u00f3n por el vih.  por estos motivos, hemos dise\u00f1ado un estudio fase iv\/i, abierto, comparativo entre dos grupos de pacientes, uno con insuficiencia hep\u00e1tica y otro control, de la farmacocin\u00e9tica de lopinavir\/ritonavir en fase de equilibrio.  de nuestro estudio hemos concluido que la insuficiencia hep\u00e1tica modifica la farmacocin\u00e9tica de los niveles de lopinavir total, lopinavir libre y ritonavir, elevando todas las concentraciones de los mismos. Estos hallazgos nos permiten aconsejar la vigilancia estrecha de los efectos adversos que puedan derivarse del aumento de los niveles plasm\u00e1ticos del f\u00e1rmaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la farmacocin\u00e9tica de lopina vii2\/ritonavir en pacientes infectados por el virus de la inmunodeficiencia humana con insuficiencia hep\u00e1tica leve o moderada<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la farmacocin\u00e9tica de lopina vii2\/ritonavir en pacientes infectados por el virus de la inmunodeficiencia humana con insuficiencia hep\u00e1tica leve o moderada <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concepci\u00f3n Cepeda Conz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Pulido Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Salamanca lorente Rafael enrique de <\/li>\n<li>Santiago Moreno guillen (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Pe\u00f1a  sanchez de rivera (vocal)<\/li>\n<li>Mar\u00eda  asuncion Hernando jerez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concepci\u00f3n Cepeda Conz\u00e1lez En los pacientes infectados por el vih de nuestro medio, la preValencia de coinfecci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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