{"id":74028,"date":"2018-03-09T23:18:57","date_gmt":"2018-03-09T23:18:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-los-potenciales-evocados-y-niveles-de-serotonina-plaquetar-en-la-comprension-de-los-mecanismos-fisiopatologicos-de-la-fibromialgia\/"},"modified":"2018-03-09T23:18:57","modified_gmt":"2018-03-09T23:18:57","slug":"utilidad-de-los-potenciales-evocados-y-niveles-de-serotonina-plaquetar-en-la-comprension-de-los-mecanismos-fisiopatologicos-de-la-fibromialgia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-de-los-potenciales-evocados-y-niveles-de-serotonina-plaquetar-en-la-comprension-de-los-mecanismos-fisiopatologicos-de-la-fibromialgia\/","title":{"rendered":"Utilidad de los potenciales evocados y niveles de serotonina plaquetar en la comprensi\u00f3n de los mecanismos fisiopatol\u00f3gicos de la fibromialgia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada M\u00e1\u00f1ez A\u00f1\u00f3n <\/strong><\/h2>\n<p>La fibromialgia (fm) es un s\u00edndrome del que se conoce muy poco respecto a su etiolog\u00eda. Los estudios m\u00e1s recientes se dirigen a intentar explicar un trastorno en la modulaci\u00f3n del dolor.  objetivos:  1. Tipificar la alteraci\u00f3n de la neuromodulaci\u00f3n mediante la utilizaci\u00f3n de una t\u00e9cnica neurofisiol\u00f3gica: dependencia del est\u00edmulo en potenciales evocados auditivos (pea)  2. Determinar el patr\u00f3n bioqu\u00edmico de la serotonina plaquetar.  3. Valorar la importancia de trastornos depresivos y del sue\u00f1o en la fm.  4. Evaluar la utilidad de instrumentos que valoran las dimensiones de la personalidad desde su sustrato biol\u00f3gicos.  material y m\u00e9todos  estudio prospectivo de casos y control. Se realiz\u00f3 valoraci\u00f3n cl\u00ednica del s\u00edndrome, niveles de serotonina hem\u00e1ticos, pea  a 60, 70, 80, 90 y 105 db, y cumplimentaci\u00f3n de cuestionarios: inventario de la depresi\u00f3n de beck, cuestionario de cloninger de la personalidad, y subescala del sue\u00f1o del mmpi.  resultados  se estudiaron a 31 casos y 29 controles pareados por la edad.  encontramos diferencias significativas en los cuestionarios de depresi\u00f3n y las subescalas del sue\u00f1o mantenimiento y despertar (p menor que  0.001). el test de cloninger muestra diferencias en la dimensi\u00f3n evitaci\u00f3n del da\u00f1o (p menor que 0.001). La serotonina plaquetar no muestras diferencias entre ambos grupos. Neurofisiol\u00f3gicamente se demuestra dependencia de la intensidad del est\u00edmulo en el grupo de fm valorado en la amplitud de 105, db (p=0.003) y mediante la pendiente de la funci\u00f3n del pea  (p=0.027). mediante regresi\u00f3n logistica, considerando la variable dependiente ser control o paciente, se obtiene una odd ratio de 6,234 para la asociaci\u00f3n entre las variables valores del tpq en la escala evitaci\u00f3n del da\u00f1o y pea a 105 db.  conclusiones.  existen diferencias entre el grupo de pacientes con fm y el grupo control en la capacidad de regulaci\u00f3n de los est\u00edmulos auditivos a nivel cor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de los potenciales evocados y niveles de serotonina plaquetar en la comprensi\u00f3n de los mecanismos fisiopatol\u00f3gicos de la fibromialgia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de los potenciales evocados y niveles de serotonina plaquetar en la comprensi\u00f3n de los mecanismos fisiopatol\u00f3gicos de la fibromialgia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada M\u00e1\u00f1ez A\u00f1\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marina Gisbert Grifo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Villanueva ca\u00f1adas <\/li>\n<li>cecilio \u00e1lamo gonz\u00e1lez (vocal)<\/li>\n<li>carmen Leal cerc\u00f3s (vocal)<\/li>\n<li>adolfo Seligra ferrer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada M\u00e1\u00f1ez A\u00f1\u00f3n La fibromialgia (fm) es un s\u00edndrome del que se conoce muy poco respecto a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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