{"id":74040,"date":"2018-03-09T23:19:02","date_gmt":"2018-03-09T23:19:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-microesferas-biodegradables-de-aciclovir-para-administracion-intraocular\/"},"modified":"2018-03-09T23:19:02","modified_gmt":"2018-03-09T23:19:02","slug":"desarrollo-de-microesferas-biodegradables-de-aciclovir-para-administracion-intraocular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-microesferas-biodegradables-de-aciclovir-para-administracion-intraocular\/","title":{"rendered":"Desarrollo de microesferas biodegradables de aciclovir para administraci\u00f3n intraocular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concepci\u00f3n Martinez Sancho <\/strong><\/h2>\n<p>El objetivo de este trabajo ha sido el desarrollo de una formulaci\u00f3n de microesferas biodergradables de aciclovir destinadas a su administraci\u00f3n por v\u00eda intraocular, en dosis \u00fanica, para el tratamiento dela infecciones herp\u00e9ticas y\/o la prevenci\u00f3nde la aparici\u00f3n de recidiva.Con este f\u00edn se ha investigado el comportamiento \u00abin vitro\u00bb de estos sistemas microparticulares elaborados con plaga de bajo peso molecular y la influencia de la estructura composici\u00f3n y caracter\u00edsticas de los mismos sobre la liberaci\u00f3n del f\u00e1rmaco encapsulado.Las microesferas se obtuvieron por el m\u00e9todo de evaporaci\u00f3n del solvente a partir de una emulsi\u00f3n o\/a.Aunque la eficacia media de encapsulaci\u00f3n delas microesferas elaboradas (properci\u00f3n 1:10 aciclovir:pol\u00edmero)result\u00f3 superior al 50% , al porcentaje de f\u00e1rmaco cadido durante los primeros 14 d\u00edas result\u00f3 hidrof\u00edlicos y lipof\u00edlicos a\u00f1adidos a la fase externa e interna de la emulsi\u00f3n ,respectivamente .Los mejores resultados se obtuvieron con las microesferas 1:2:10 (aciclovir:gelatina:pol\u00edmero).Para optimizar la formulaci\u00f3n y reducir la cantidad de microesferas a administrar,se aplic\u00f3 un dise\u00f1o central rotacional 2 estrellas considerando como variables el aciclovir y la gelatina.Los par\u00e1metros estudiados condujer\u00f3n a unos resultados muy favorables par la formulaci\u00f3n 2:2:10(aciclovir:gelatina:pol\u00edmero), disminuyendo en un 40% la cantidad de microesferas a administrar con respecto a la formulaci\u00f3m1:2:10, por lo que fue la formulaci\u00f3n seleccionada para posteriors estudios.Dicha formulaci\u00f3n fue sometida a una dosis de radiaci\u00f3n gamma de 25kgy en condiciones especiales .Todos los ensayos realizados demostrar\u00f3n qu las microesferas no sufren modificaci\u00f3n tras la esterilizaci\u00f3n siendo adecuadas para aplicar en un modelo animal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de microesferas biodegradables de aciclovir para administraci\u00f3n intraocular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de microesferas biodegradables de aciclovir para administraci\u00f3n intraocular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concepci\u00f3n Martinez Sancho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Negro Alvarez M. Sofia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Molina Martinez irene teresa <\/li>\n<li>carmen Mar\u00eda Evora Garc\u00eda (vocal)<\/li>\n<li>margarita Arboix arbo (vocal)<\/li>\n<li>coloma Barbe rocabert (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concepci\u00f3n Martinez Sancho El objetivo de este trabajo ha sido el desarrollo de una formulaci\u00f3n de microesferas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[3221,160533,160531,5678,81670,160532],"class_list":["post-74040","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carmen-maria-evora-garcia","tag-coloma-barbe-rocabert","tag-concepcion-Martinez-sancho","tag-margarita-arboix-arbo","tag-molina-Martinez-irene-teresa","tag-negro-alvarez-m-sofia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74040"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74040\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}