{"id":74089,"date":"2018-03-09T23:19:02","date_gmt":"2018-03-09T23:19:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-y-caracterizacion-bioqua%c2%admica-de-autoanticuerpos-dirigidos-frente-al-receptor-endotelial-de-la-protea%c2%adna-c-y-su-papel-en-el-desarrollo-de-trombosis\/"},"modified":"2018-03-09T23:19:02","modified_gmt":"2018-03-09T23:19:02","slug":"determinacion-y-caracterizacion-bioqua%c2%admica-de-autoanticuerpos-dirigidos-frente-al-receptor-endotelial-de-la-protea%c2%adna-c-y-su-papel-en-el-desarrollo-de-trombosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/determinacion-y-caracterizacion-bioqua%c2%admica-de-autoanticuerpos-dirigidos-frente-al-receptor-endotelial-de-la-protea%c2%adna-c-y-su-papel-en-el-desarrollo-de-trombosis\/","title":{"rendered":"Determinaci\u00f3n y caracterizaci\u00f3n bioqu\u00edmica de autoanticuerpos dirigidos frente al receptor endotelial de la prote\u00edna c y su papel en el desarrollo de trombosis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Veronica Hurtado Linares <\/strong><\/h2>\n<p>Determinaci\u00f3n y caracterizaci\u00f3n bioqu\u00edmica de autoanticuerpos dirigidos frente al receptor endotelial de la proteina c y su papel en el desarrollo de trombosis.  resumen: el receptor de la proteina c (epcr) desempe\u00f1a un importante papel en el sistema anticoagulante y en el desarrollo placentario por lo que   supusimos que autoanticuerpos anti-epcr podr\u00edan estar implicados en las cl\u00ednicas del s\u00edndrome antifosfol\u00edpido (aps) y del infarto agudo de miocardio (ami). Los niveles de autoanticuerpos anti-epcr inmunoglobulina m (igm) e igg fueron analizados por elisa en 43 pacientes con aps y 43 controles pareados. Uno de los autoanticuepos anti-epcr igm inhibi\u00f3 la generaci\u00f3n de prote\u00edna activada c sobre el endotelio. Ya que hubo niveles de anti-epcr altos en mujeres con muerte fetal, se analiz\u00f3 87 pacientes con un primer episodio de muerte fetal y 87 controles emparejados. Los autoanticuerpos anti-epcr constituyeron un factor de riesgo independiente para este grupo: la odds ratios (ors) encima del percentil 95 fue 23.0 (el intervalo de confianza al 95 % [ci], 2.0-266.3) para igm y 6.8 (95 % ci, 1.2-38.4) para igg. Los niveles de anti-epcr igm, iga y igg se  midieron en 165 mujeres menores de 45 a\u00f1os que sobrevivieron a un primer ami y 165 controles emparejados, usando el percentil 90 de anti-epcr iga del grupo de control, encontramos que los anti-epcr iga se asociaron con ami despu\u00e9s de ajustar por los factores de riesgo cardiovasculares (or 5.1; 95% ci 1.7-15.6; p=0.004) y tambi\u00e9n con efecto dosis dependientemente (p de tendencia =0.0002). Los anti-epcr igm por encima del percentil 90 aumentaron significativamente el riesgo comparado con cuartiles m\u00e1s bajos (or 3.6; el 95 % ci 1.2-11.5; p = 0.03).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n y caracterizaci\u00f3n bioqu\u00edmica de autoanticuerpos dirigidos frente al receptor endotelial de la prote\u00edna c y su papel en el desarrollo de trombosis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n y caracterizaci\u00f3n bioqu\u00edmica de autoanticuerpos dirigidos frente al receptor endotelial de la prote\u00edna c y su papel en el desarrollo de trombosis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Veronica Hurtado Linares <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Hermida Santos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Jes\u00fas Lopez zabalza <\/li>\n<li>Javier Corral de la calle (vocal)<\/li>\n<li>ignacio Alberca silva (vocal)<\/li>\n<li>pablo Garc\u00eda de frutos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Veronica Hurtado Linares Determinaci\u00f3n y caracterizaci\u00f3n bioqu\u00edmica de autoanticuerpos dirigidos frente al receptor endotelial de la proteina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,36483,160,17749],"tags":[55862,160631,74560,18030,77182,160630],"class_list":["post-74089","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-biologia-molecular","category-bioquimica","category-navarra","tag-ignacio-alberca-silva","tag-javier-corral-de-la-calle","tag-jose-maria-hermida-santos","tag-maria-jesus-lopez-zabalza","tag-pablo-garcia-de-frutos","tag-veronica-hurtado-linares"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74089"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74089\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}