{"id":74177,"date":"2018-03-09T23:19:11","date_gmt":"2018-03-09T23:19:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-locus-ink4a-arf-efecto-de-los-inhibidores-de-deacetilasas-de-histonas-y-generacion-de-ratones-modificados-geneticamente\/"},"modified":"2018-03-09T23:19:11","modified_gmt":"2018-03-09T23:19:11","slug":"regulacion-de-locus-ink4a-arf-efecto-de-los-inhibidores-de-deacetilasas-de-histonas-y-generacion-de-ratones-modificados-geneticamente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-de-locus-ink4a-arf-efecto-de-los-inhibidores-de-deacetilasas-de-histonas-y-generacion-de-ratones-modificados-geneticamente\/","title":{"rendered":"Regulacion de locus ink4a\/arf. efecto de los inhibidores de deacetilasas de histonas y generacion de ratones modificados geneticamente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ander Matheu Fernandez <\/strong><\/h2>\n<p>El locus ink4a\/arf tiene gran importancia en la defensa del organismo frente al c\u00e1ncer. En concreto, sus miembros forman parte de las v\u00edas supresoras m\u00e1s importantes conocidas, ink4a\/rb y arf\/p53. En este trabajo, hemos profundizado en la acci\u00f3n supresora del locus ink4a\/arf investigando su regulaci\u00f3n por drogas quimioterap\u00e9uticas y mediante la generaci\u00f3n de nuevos modelos animales.  en primer lugar, hemos investigado el efecto que tienen los inhibidores de desacetilasas de histonas (hdacis) en la expresi\u00f3n de ink4a y arf. Los hdacis regulan la expresi\u00f3n de un gran n\u00famero de genes y exhiben una potente actividad citost\u00e1tica. Hemos observado que los hdacis modulan transcripcionalmente la expresi\u00f3n de los miembros del locus ink4a\/arf. Los hdacis reprimen la expresi\u00f3n de ink4a e inducen la expresi\u00f3n de arf. Hemos observado que la asociaci\u00f3n del factor de transcripci\u00f3n sp-1 al promotor de ink4a es necesaria para el efecto represor de los hdacis sobre ink4a. Por otro lado, hemos descubierto que la activaci\u00f3n de arf desarrolla un importante papel en la parada del ciclo celular inducida por hdacis. Por \u00faltimo, demostramos que la acci\u00f3n antitumoral realizada por los hdacis est\u00e1 mediada por la activaci\u00f3n de arf.  las consecuencias negativas que conlleva la p\u00e9rdida funcional de ink4a y arf han sido ampliamente caracterizadas en el pasado. Se han generado diferentes modelos animales deficientes en ink4a y\/o arf que se caracterizan por el desarrollo de tumores a edad temprana. Estamos interesados en estudiar los efectos beneficiosos frente al c\u00e1ncer obtenidos por el aumento en la dosis g\u00e9nica de ink4a y arf. Para ello, hemos generado un modelo animal con una copia g\u00e9nica extra del locus ink4b\/ink4a\/arf \u00edntegro. Previo a este trabajo, en el laboratorio hemos generado l\u00edneas de ratones con copias g\u00e9nicas extra de p53. Este modelo \u00abs\u00faper p53\u00bb presenta resistencia incrementada al desarrollo de tumores sin verse afectados ot<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de locus ink4a\/arf. efecto de los inhibidores de deacetilasas de histonas y generacion de ratones modificados geneticamente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de locus ink4a\/arf. efecto de los inhibidores de deacetilasas de histonas y generacion de ratones modificados geneticamente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ander Matheu Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Serrano Marug\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jorgina Satr\u00fastegui gil-delgado <\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Carlos Lopez otin (vocal)<\/li>\n<li>ignacio Palmero rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ander Matheu Fernandez El locus ink4a\/arf tiene gran importancia en la defensa del organismo frente al c\u00e1ncer. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[160775,5834,45079,40871,6755,41977],"class_list":["post-74177","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","tag-ander-matheu-fernandez","tag-carlos-lopez-otin","tag-ignacio-palmero-rodriguez","tag-isidro-javier-sanchez-garcia","tag-jorgina-satrustegui-gil-delgado","tag-manuel-serrano-marugan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74177"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74177\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}