{"id":74202,"date":"2018-03-09T23:19:11","date_gmt":"2018-03-09T23:19:11","guid":{"rendered":""},"modified":"2018-03-09T23:19:11","modified_gmt":"2018-03-09T23:19:11","slug":"valor-pronostico-de-la-densidad-microvascular-y-de-la-expresion-de-factores-angigonicos-vegf-angiopoietina-2-y-cox-2-y-proteasas-upa-pai-1-y-mmps-en-pacientes-con-cancer-gastrico-intervenidos-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-densidad-microvascular-y-de-la-expresion-de-factores-angigonicos-vegf-angiopoietina-2-y-cox-2-y-proteasas-upa-pai-1-y-mmps-en-pacientes-con-cancer-gastrico-intervenidos-c\/","title":{"rendered":"Valor pron\u00f3stico de la densidad microvascular y de la expresi\u00f3n de factores angig\u00f3nicos (vegf, angiopoietina 2, y cox-2) y proteasas (upa, pai-1 y mmps) en pacientes con c\u00e1ncer g\u00e1strico intervenidos con pretensi\u00f3n curativa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Vidal P\u00e9rez <\/strong><\/h2>\n<p>Introducci\u00f3n  aunque la incidencia global del c\u00e1ncer g\u00e1strico (cg) est\u00e1 disminuyendo en el mundo desarrollado, esta neoplasia contin\u00faa siendo la segunda causa de muerte por c\u00e1ncer. Un mejor conocimiento de los mecanismos implicados en la carcinog\u00e9nesis g\u00e1strica puede ayudar a identificar dianas moleculares susceptibles de intervenci\u00f3n terap\u00e9utica.  objetivo  evaluar el valor predictivo de diversos factores moleculares implicados en la angiog\u00e9nesis y la degradaci\u00f3n de la matriz extracelular en relaci\u00f3n con la supervivencia global y la recurrencia en pacientes con cg tras una resecci\u00f3n quir\u00fargica con finalidad radical.  m\u00e9todos  se han evaluado 148 pacientes con cg tratados en nuestra unidad con resecciones curativas (ro). En todos ellos se ha determinado la expresi\u00f3n de metaloproteinasas de la matriz 1 y 9 (mmp-1 y mmp-9), activador del  plasmin\u00f3geno tipo uroquinasa (upa), inhibidor del activador del plasmin\u00f3geno (pai-1), ciclooxigenasa 2 (cox-2), angiopoyetina 2 (ang-2), factor de crecimiento del endotelio vascular (vegf), p53 y la densidad microvascular (mvd) en el tumor primario mediante inmunohistoqu\u00edmica. Asimismo, se han evaluado 14 variables epidemiol\u00f3gicas (edad y sexo), histol\u00f3gicas (estadio ptnm, grado de diferenciaci\u00f3n, clasificaci\u00f3n de lauren, existencia de c\u00e9lulas en anillo de sello, grado de curabilidad, invasi\u00f3n vascular, linf\u00e1tica y perineural, y cociente ganglios afectos\/resecados) y terap\u00e9uticas (tipo de cirug\u00eda y delinfadenectom\u00eda, y quimioterapia). se efectu\u00f3 un an\u00e1lisis univariante (kaplan-meier, log-rank) y multivariante (cox) con el fin de seleccionar los factores con valor pron\u00f3stico independiente as\u00ed como ajustar los resultados del estudio molecular con las variables cl\u00ednicas significativas (p0,05).  resultados  la edad media fue de 68 a\u00f1os y el 67% eran hombres. El tiempo medio de supervivencia fue de 56+-4 meses, siendo la probabilidad de supervivencia global a los 2,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la densidad microvascular y de la expresi\u00f3n de factores angig\u00f3nicos (vegf, angiopoietina 2, y cox-2) y proteasas (upa, pai-1 y mmps) en pacientes con c\u00e1ncer g\u00e1strico intervenidos con pretensi\u00f3n curativa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la densidad microvascular y de la expresi\u00f3n de factores angig\u00f3nicos (vegf, angiopoietina 2, y cox-2) y proteasas (upa, pai-1 y mmps) en pacientes con c\u00e1ncer g\u00e1strico intervenidos con pretensi\u00f3n curativa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Vidal P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Pera  Rom\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Calpena <\/li>\n<li>jean-philippe Metges (vocal)<\/li>\n<li>Juan  Carlos Garc\u00eda-valdecasas salgado (vocal)<\/li>\n<li>cristobal Mezquita (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Vidal P\u00e9rez Introducci\u00f3n aunque la incidencia global del c\u00e1ncer g\u00e1strico (cg) est\u00e1 disminuyendo en el mundo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9],"tags":[160822,160821,1155,24960,139443,160820],"class_list":["post-74202","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","tag-cristobal-mezquita","tag-jean-philippe-metges","tag-juan-carlos-garcia-valdecasas-salgado","tag-manuel-pera-roman","tag-oscar-vidal-perez","tag-rafael-calpena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74202"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74202\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}