{"id":74232,"date":"2018-03-09T23:19:15","date_gmt":"2018-03-09T23:19:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/functional-characterization-of-the-novel-protein-ptov1-caracterizacion-funcional-de-la-nueva-protea%c2%adna-ptov1\/"},"modified":"2018-03-09T23:19:15","modified_gmt":"2018-03-09T23:19:15","slug":"functional-characterization-of-the-novel-protein-ptov1-caracterizacion-funcional-de-la-nueva-protea%c2%adna-ptov1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/functional-characterization-of-the-novel-protein-ptov1-caracterizacion-funcional-de-la-nueva-protea%c2%adna-ptov1\/","title":{"rendered":"Functional characterization of the novel protein ptov1 (caracterizaci\u00f3n funcional de la nueva prote\u00edna ptov1)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Santamar\u00eda Margalef <\/strong><\/h2>\n<p>La presente tesis doctoral se divide en 3 partes:  la primera parte y central, analiza las caracterizaci\u00f3n funcional de la prote\u00edna ptov1. Dicha prote\u00edna fue hallada en un experimento de differential display realizado con muestras de adenocarcinoma prost\u00e1tico y muestras normales.  ptov1 se halla sobreexpresada en c\u00e1ncer de pr\u00f3stata (cp) y en lesiones de pin. Ptov1 es necesaria para la proliferaci\u00f3n celular. Cuando se sobreexpresa, como ocurre en cp, las c\u00e9lulas entran en estado proliferativo. Adem\u00e1s la sobreexpresi\u00f3n de ptov1 en tumores tambi\u00e9n se correlaciona con una mayor estado proliferativo de \u00e9stos. Ptov1 interacciona con flotillin-1, prote\u00edna mayoritaria delos lipid rafts no caveolares. Ptov1 parece ser necesaria para la entrada a n\u00facleo de flotillin-1. La sobreexpresi\u00f3n de flotillin-1 tambi\u00e9n induce la proliferaci\u00f3n celular y ambas parecen depender de la rec\u00edproca en su actividad mitog\u00e9nica. Flotillin-1 parece tambi\u00e9n intervenir en mecanismos reguladores de la mitosis. Por otro lado, ptov1 induce un aumento de la capacidad invasiva de las c\u00e9lulas in vitro. La sobreexpresi\u00f3n e ptov1 induce un aumento de los niveles de las proteass del sistema del plasmin\u00f3geno upa y upar. Ptov1 interacciona con la prote\u00edna rack1. Ambas se translocan a la membrana bajo la estimulaci\u00f3n con igf-1 o pma. Ambas podr\u00edan participar en procesos de polarizaci\u00f3n y\/o migraci\u00f3n celular.  la segunda parte de la tesis, aborda el estudio de la prote\u00edna clusterin 1 y su papel inductor de la apoptosis en la l\u00ednea tumoral prost\u00e1tica pc-3. se analiza con detalle los efectos que promueve una forma intracelular de la prote\u00edna transfectada tanto de forma transitoria como estable en dicha l\u00ednea celular. La sobreexpresi\u00f3n de la forma nuclear de clusterin1 induce el arresto en g2\/m y la apoptosis celular. Por \u00faltimo, la tercera parte de la tesis, aborda es estudio de los efectos antiproliferativos de los exactos de pygeum africanum sobre<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Functional characterization of the novel protein ptov1 (caracterizaci\u00f3n funcional de la nueva prote\u00edna ptov1)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Functional characterization of the novel protein ptov1 (caracterizaci\u00f3n funcional de la nueva prote\u00edna ptov1) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Santamar\u00eda Margalef <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosanna Paciucci Barzanti<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zorzano olarte <\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<li>gabriel Capella munar (vocal)<\/li>\n<li>santos Ma\u00f1es (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Santamar\u00eda Margalef La presente tesis doctoral se divide en 3 partes: la primera parte y central, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,160,115,35,9399,17],"tags":[160878,20202,33983,50841,36351,120545],"class_list":["post-74232","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-cultivo-celular","category-quimica","tag-anna-santamaria-margalef","tag-antonio-zorzano-olarte","tag-gabriel-capella-munar","tag-rosanna-paciucci-barzanti","tag-santiago-ramon-y-cajal-agieras","tag-santos-manes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74232"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74232\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}