{"id":74260,"date":"2005-01-06T00:00:00","date_gmt":"2005-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-transicion-epiteli-mesenquima-en-celulas-tumorales-papel-de-snail-y-otros-factores-transcripcionales\/"},"modified":"2005-01-06T00:00:00","modified_gmt":"2005-01-06T00:00:00","slug":"regulacion-de-la-transicion-epiteli-mesenquima-en-celulas-tumorales-papel-de-snail-y-otros-factores-transcripcionales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-de-la-transicion-epiteli-mesenquima-en-celulas-tumorales-papel-de-snail-y-otros-factores-transcripcionales\/","title":{"rendered":"Regulaci\u00f3n de la transici\u00f3n epiteli-mesenquima en c\u00e9lulas tumorales: \u00abpapel de snail y otros factores transcripcionales\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Puig Borrell <\/strong><\/h2>\n<p>El mal pron\u00f3stico en una neoplasia epitelial est\u00e1 asociada a la adquisici\u00f3n de caracter\u00edsticas m\u00f3biles e invasivas por parte de las c\u00e9lulas cancerosas. esta transformaci\u00f3n morfol\u00f3gica se denomina transici\u00f3n epitelio-mes\u00e9nquima (tem). Durante este proceso, los marcadores epiteliales son regulados negativamente, uno de los m\u00e1s importantes es la prote\u00edna de adhesi\u00f3n e-cadherina. El factor transcripcional snail reprime la transcripci\u00f3n de la e-cadherina a trav\u00e9s de su uni\u00f3n a unas secuencias de reconocimiento denominadas caja-e y situadas en el promotor de la e-cadherina. En este trabajo se ha examinado con mayor detalle los cambios inducidos por la expresi\u00f3n ect\u00f3pica de snail en c\u00e9lulas epiteliales. Las c\u00e9lulas que expresan snail presentan un fenotipo estirado con muy pocos contactos celulares. Otros marcadores epiteliales adem\u00e1s de la e-cadherina son reprimidos, como la citoqueratina-18 y muc1. Los efectos represores de snail sobre la transcripci\u00f3n de muc1 son mediados a trav\u00e9s de dos cajas-e presentes en su promotor proximal. Adem\u00e1s snail tiene la capacidad de inducir la expresi\u00f3n de marcadores mesenquimales t\u00edpicos como la fibronectina, lef1 y el represor transcripcional zeb1. la sobreexpresi\u00f3n de snail en diversas lineas celulares provoca un aumento de los niveles de arnm de zeb1 y un incremento de la actividad de su promotor. tambi\u00e9n se ha estudiado la regulaci\u00f3n de la expresi\u00f3n de snail durante el proceso de tem. El promotor de snail est\u00e1 activado en aquellas lineas celulares que han sido inducidas a sufrir un proceso de tem. Aunque son necesarias otras regiones del promotor de snail para obtener su completa estimulaci\u00f3n por akt o ilk, el fragmento m\u00ednimo del promotor denominado (-78\/+59) es suficiente para mantener la especificidad mesenquimal. La actividad del promotor m\u00ednimo de snail y sus niveles de arnm dependen de la se\u00f1alizaci\u00f3n de erk. El factor transcripcional nfkb\/p65 tambi\u00e9n es capaz de es<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la transici\u00f3n epiteli-mesenquima en c\u00e9lulas tumorales: \u00abpapel de snail y otros factores transcripcionales\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la transici\u00f3n epiteli-mesenquima en c\u00e9lulas tumorales: \u00abpapel de snail y otros factores transcripcionales\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Puig Borrell <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garcia De Herreros Madue\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis De la pompa minguez <\/li>\n<li>ra\u00fal M\u00e9ndez de la iglesia (vocal)<\/li>\n<li>anna Bigas salvans (vocal)<\/li>\n<li>joan Seoane suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Puig Borrell El mal pron\u00f3stico en una neoplasia epitelial est\u00e1 asociada a la adquisici\u00f3n de caracter\u00edsticas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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