{"id":74292,"date":"2005-03-06T00:00:00","date_gmt":"2005-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tumores-estromales-gastrointestinales-estudio-cla%c2%adnico-patologico-e-inmunohistoqua%c2%admico-mediante-tissue-microarrays\/"},"modified":"2005-03-06T00:00:00","modified_gmt":"2005-03-06T00:00:00","slug":"tumores-estromales-gastrointestinales-estudio-cla%c2%adnico-patologico-e-inmunohistoqua%c2%admico-mediante-tissue-microarrays","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tumores-estromales-gastrointestinales-estudio-cla%c2%adnico-patologico-e-inmunohistoqua%c2%admico-mediante-tissue-microarrays\/","title":{"rendered":"Tumores estromales gastrointestinales. estudio cl\u00ednico &#8211; patol\u00f3gico e inmunohistoqu\u00edmico mediante tissue microarrays"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquin Gonz\u00e1lez-carrer\u00f3 Foj\u00f3n <\/strong><\/h2>\n<p>El tumor estromal gastrointestinal (gist) ha cobrado una especial importancia, a pesar de su relativa infrecuencia, por ser la primera neoplasia s\u00f3lida con un tratamiento eficaz dirigido a una diana molecular concreta: la inhibici\u00f3n por el mesilato de imatinib de la funci\u00f3n tiros \u00edn-quinasa de la prote\u00edna kit mutada.  en esta serie estudiamos 84 casos de gist desde el punto de vista cl\u00ednico, patol\u00f3gico e inmunohistoqu\u00edmico intentando identificar las variables que mejor predicen el pron\u00f3stico. Para ello empleamos la tecnolog\u00eda de los tissue microarrays, que permite la evaluaci\u00f3n de los marcadores inmunohistoqu\u00edmicos de cientos de muestras tisulares en la misma preparaci\u00f3n. La inmunotinci\u00f3n para kit, que es recomendable pero no imprescindible para el diagn\u00f3stico, ofrece mejores resultados con el policlonal a4502 (dako) a una diluci\u00f3n de 1:100 con pretratamiento por calor. La proliferaci\u00f3n se eval\u00faa mejor a trav\u00e9s del \u00edndice mib-1 que con la contabilidad directa de las mitosis. los tumores g\u00e1stricos son con su mayor frecuencia epitolioides y son menos agresivos que los situados en el intestino delgado. De todos los reguladores del ciclo celular y de la apoptosis evaluados, el \u00fanico que muestra tener relevancia pron\u00f3stica es p53, por lo que puede ser aconsejable a\u00f1adir este marcador al estudio del gist.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tumores estromales gastrointestinales. estudio cl\u00ednico &#8211; patol\u00f3gico e inmunohistoqu\u00edmico mediante tissue microarrays<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tumores estromales gastrointestinales. estudio cl\u00ednico &#8211; patol\u00f3gico e inmunohistoqu\u00edmico mediante tissue microarrays <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquin Gonz\u00e1lez-carrer\u00f3 Foj\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Forteza Vila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Garc\u00eda caballero parada <\/li>\n<li>Francisco Javier Pardo mind\u00e1n (vocal)<\/li>\n<li>pedro Gil gil (vocal)<\/li>\n<li>mercedes Butr\u00f3n vila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquin Gonz\u00e1lez-carrer\u00f3 Foj\u00f3n El tumor estromal gastrointestinal (gist) ha cobrado una especial importancia, a pesar de su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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