{"id":7432,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/implicacion-del-calcio-en-los-efectos-perifericos-de-ligandos-de-receptores-benzodiacepinicos-en-aorta-de-rata\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"implicacion-del-calcio-en-los-efectos-perifericos-de-ligandos-de-receptores-benzodiacepinicos-en-aorta-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-del-calcio-en-los-efectos-perifericos-de-ligandos-de-receptores-benzodiacepinicos-en-aorta-de-rata\/","title":{"rendered":"\u00abimplicacion del calcio en los efectos perifericos de ligandos de receptores benzodiacepinicos, en aorta de rata\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Aurelio Abengoechea Cotaina <\/strong><\/h2>\n<p>Las benzodiacepinas pueden unirse a dos tipos de receptores: perifericos y centrales. El primero constituye un sitio especifico del complejo molecular gabaa, cuya activacion facilita la apertura del canal de c1- en respuesta al gaba, mecanismo que explica los efectos de estas sustancias sobre estructuras del sistema nervioso central.  el periferico ha sido descrito en numerosos territorios, pero no se ha caracterizado su funcion ni los mecanismos bioquimicos con los que pudiera estar implicado, aunque se le ha relacionado con la secrecion esteroidea, metabolismo mitocondrial y homeostasis del calcio.  el objetivo de esta tesis doctoral, en relacion con el ultimo mecanismo comentado, ha sido caracterizar el efecto de diversos ligandos de receptores benzodiacepinicos (ro 5-4864, pk 11195, diazepam, midazolam, flumazenil y protoporfirina ix) sobre la contractilidad de la aorta toracica aislada de rata inducida por agentes espasmogenos cuya respuesta depende de la entrada de calcio al interior de la celula y\/o movilizacion de depositos intracelulares (c12ca, c1k, serotonina y noradrenalina). Los resultados obtenidos nos sugieren:  1. Los ligandos de receptores benzodiacepinicos ro 5-4864, pk 11195, diazepam y midazolam, pero no flumazenil ni protoporfirina ix, inhiben, a concentraciones micromolares, la respuesta contractil inducida, de forma concentracion-dependiente, por c12ca, c1k, serotonina y noradrenalina, en la aorta toracica aislada de rata.  2. Este efecto parece relacionado con su interaccion con sitios especificos de union de baja afinidad, ligados funcionalmente a canales de calcio tipo l, en la membrana citoplamatica, de la que derivaria un bloqueo de los mismos, debido a que presentan una cierta selectividad por los estimulos dependientes de voltaje, en comparacion con los mediados por receptores.  3. Dado que a las concentraciones mas elevadas se pierde la selectividad comentada, sugerimos acciones adicionales i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abimplicacion del calcio en los efectos perifericos de ligandos de receptores benzodiacepinicos, en aorta de rata\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abimplicacion del calcio en los efectos perifericos de ligandos de receptores benzodiacepinicos, en aorta de rata\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Aurelio Abengoechea Cotaina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Esplugues Requena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Morcillo Sanchez <\/li>\n<li>Victor Gimenez Torres (vocal)<\/li>\n<li>Pedro Lorenzo Fernandez (vocal)<\/li>\n<li>Jes\u00fas Honorato Perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Aurelio Abengoechea Cotaina Las benzodiacepinas pueden unirse a dos tipos de receptores: perifericos y centrales. El [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189],"tags":[26783,11462,17752,11461,898,26784],"class_list":["post-7432","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-antonio-aurelio-abengoechea-cotaina","tag-esteban-morcillo-sanchez","tag-jesus-honorato-perez","tag-juan-esplugues-requena","tag-pedro-lorenzo-fernandez","tag-victor-gimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7432"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7432\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}