{"id":74366,"date":"2005-06-06T00:00:00","date_gmt":"2005-06-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-del-fracaso-multiorganico-mediante-deplecion-macrofagica-en-un-modelo-de-politraumatismo-experimental\/"},"modified":"2005-06-06T00:00:00","modified_gmt":"2005-06-06T00:00:00","slug":"modulacion-del-fracaso-multiorganico-mediante-deplecion-macrofagica-en-un-modelo-de-politraumatismo-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-del-fracaso-multiorganico-mediante-deplecion-macrofagica-en-un-modelo-de-politraumatismo-experimental\/","title":{"rendered":"Modulaci\u00f3n del fracaso multiorg\u00e1nico mediante depleci\u00f3n macrof\u00e1gica en un modelo de politraumatismo experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Torralbo Eva M. <\/strong><\/h2>\n<p>Debido a los avances de los \u00faltimos a\u00f1os en el cuidado de enfermos cr\u00edticos, ha sugerido un nuevo tipo de paciente, el paciente cr\u00f3nicamente cr\u00edtico o con s\u00edndrome de disfunci\u00f3n multiorg\u00e1nica (mods).  un 30% de los pacientes politraum\u00e1ticos desarrollan un mods, constituyendo la principal causa de muerte en \u00e9stos transcurridas las primeras 24 horas tras la agresi\u00f3n.  la disfunci\u00f3n secuencial de \u00f3rganos aparece despu\u00e9s de un periodo de d\u00edas o semanas del insulto original.  generalmente empieza por un fracaso respiratorio seguido de fracaso intestinal, hep\u00e1tico, renal, hematol\u00f3gico y cardiaco. El orden exacto de aparici\u00f3n var\u00eda en funci\u00f3n de las enfermedades preexistentes y de la naturaleza del insulto causal. La mortalidad se correlaciona con el n\u00famero de \u00f3rganos afectados as\u00ed como con la edad y duraci\u00f3n de la disfunci\u00f3n org\u00e1nica.  durante tres d\u00e9cadas, las investigaciones se han centrado en encontrar un agente espec\u00edfico como causa del mods. Inicialmente, se crey\u00f3 que era una infecci\u00f3n incontrolada la que precipitaba la disfunci\u00f3n multiorg\u00e1nica. posteriormente qued\u00f3 claro que la infecci\u00f3n era el est\u00edmulo iniciador en s\u00f3lo la mitad de los pacientes con mods, en el otro 50% este s\u00edndrome ocurre sin identificar un foco infeccioso. As\u00ed, los estudios se centraron en la respuesta del hu\u00e9sped frente a la agresi\u00f3n. Una reacci\u00f3n inflamatoria localizada es una respuesta fisiol\u00f3gica protectora que es controlada por el organismo en el lugar de la agresi\u00f3n. La p\u00e9rdida del control local o una desmesurada activaci\u00f3n de esta respuesta, da lugar a una exagerada respuesta sist\u00e9mica identificada cl\u00ednicamente como sirs. Ante esta situaci\u00f3n se activan unos mecanismos compensadores y el resultado final (resoluci\u00f3n, mods o muerte), depende del balance entre el sirs y sus mecanismos compensadores (cars). se desarrolla un mods cuando las respuestas inflamatoria o anti-inflamatoria del hu\u00e9sped a la agresi\u00f3n (o a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n del fracaso multiorg\u00e1nico mediante depleci\u00f3n macrof\u00e1gica en un modelo de politraumatismo experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n del fracaso multiorg\u00e1nico mediante depleci\u00f3n macrof\u00e1gica en un modelo de politraumatismo experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Torralbo Eva M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Sanchez Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xavier Rius cornado <\/li>\n<li>pere Rebasa cladera (vocal)<\/li>\n<li>Juan S\u00e1nchez-lloret tortosa (vocal)<\/li>\n<li>jordi Mancebo cort\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Torralbo Eva M. Debido a los avances de los \u00faltimos a\u00f1os en el cuidado de enfermos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279],"tags":[161125,45489,33860,1041,96416,9781],"class_list":["post-74366","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","tag-garcia-torralbo-eva-m","tag-jordi-mancebo-cortes","tag-jose-sanchez-ortega","tag-juan-sanchez-lloret-tortosa","tag-pere-rebasa-cladera","tag-xavier-rius-cornado"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74366"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74366\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}