{"id":74427,"date":"2005-09-06T00:00:00","date_gmt":"2005-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-genica-y-de-los-mecanismos-de-muerte-celular-inducidos-por-la-bisantraciclina-wp631-en-celulas-tumorales-humanas\/"},"modified":"2005-09-06T00:00:00","modified_gmt":"2005-09-06T00:00:00","slug":"analisis-de-la-expresion-genica-y-de-los-mecanismos-de-muerte-celular-inducidos-por-la-bisantraciclina-wp631-en-celulas-tumorales-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-la-expresion-genica-y-de-los-mecanismos-de-muerte-celular-inducidos-por-la-bisantraciclina-wp631-en-celulas-tumorales-humanas\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n g\u00e9nica y de los mecanismos de muerte celular inducidos por la bisantraciclina wp631 en c\u00e9lulas tumorales humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sylvia Mansilla Barrado <\/strong><\/h2>\n<p>Nuestro grupo ha participado en el an\u00e1lisis de los mecanismos de acci\u00f3n dela bisantraciclina wp631. Hemos comparado los efectos de la wp631 con los dos de la daunorubicina en la l\u00ednea jurkat t (leucemia de linfocitos t), y con los de la doxorubicina en las l\u00edneas mda-mb-231 y mcf-7\/vp (l\u00edneas de carcinoma mamario).  hemos demostrado que la wp631 es un agente antiproliferativo mucho m\u00e1s eficaz que la daunorubicina y la doxorubicina en las tres l\u00edneas tumorales analizadas, ya que inhibe el crecimiento celular a dosis muy reducidas (en el rango de nanomolar).  en este trabajo se han analizado los mecanismos de muerte celular a trav\u00e9s de los cuales las antraciclinas ejercen su efecto antiproliferativo. Hemos demostrado que estas mol\u00e9culas pueden inducir mecanismos distintos a la apoptosis dependiente de p53: senescencia y cat\u00e1strofe mit\u00f3tica, procesos que no dependen necesariamente de la funcionalidad del gen p53.  los efectos antiproliferativos de la daunorubicina sobre las c\u00e9lulas leuc\u00e9micas jurkat t dependen de la dosis utilizada: apoptosis a dosis altas (ic75) y senescencia a dosis bajas\/moderadas (ic50). La wp631 no induce apoptosis en la l\u00ednea jurkat t, sino cat\u00e1strofe mit\u00f3tica. El efecto antiproliferativo de la doxorubicina y la wp631 en las l\u00edneas de carcinoma mamario mda-mb-231 y mcf-7\/vp, resistentes a la apoptosis, tiene lugar a trav\u00e9s de la inducci\u00f3n de cat\u00e1strofe mit\u00f3tica. Nuestros resultados demuestran que la cat\u00e1strofe mit\u00f3tica se produce cuando las c\u00e9lulas tumorales resistentes a la apoptosis se tratan con genot\u00f3xicos, y puede ser un proceso tanto dependiente como independiente de la activaci\u00f3n de la caspasa-2 y la caspasa-3.  mediante el uso de macroarrays, hemos demostrado que existe una clara correlaci\u00f3n entre las variaciones en los perfiles  de transcripci\u00f3n gen\u00e9tica y los efectos celulares observados en c\u00e9lulas jurkat t tratadas con daunorubicina o wp631.  confirmamos algunos de los cam<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la expresi\u00f3n g\u00e9nica y de los mecanismos de muerte celular inducidos por la bisantraciclina wp631 en c\u00e9lulas tumorales humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n g\u00e9nica y de los mecanismos de muerte celular inducidos por la bisantraciclina wp631 en c\u00e9lulas tumorales humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sylvia Mansilla Barrado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Portugal Minguela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: silvia Atrian ventura <\/li>\n<li> Mart\u00ednez beltras m. angeles (vocal)<\/li>\n<li>angels Fabra fres (vocal)<\/li>\n<li>timothy Thausan oletsun (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sylvia Mansilla Barrado Nuestro grupo ha participado en el an\u00e1lisis de los mecanismos de acci\u00f3n dela bisantraciclina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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