{"id":74428,"date":"2005-09-06T00:00:00","date_gmt":"2005-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/recurrencia-de-la-infeccion-por-el-virus-de-la-hepatitis-c-vhc-tras-el-trasplante-hepatico-factores-predictivos-de-recidiva-precoz-y-grave\/"},"modified":"2005-09-06T00:00:00","modified_gmt":"2005-09-06T00:00:00","slug":"recurrencia-de-la-infeccion-por-el-virus-de-la-hepatitis-c-vhc-tras-el-trasplante-hepatico-factores-predictivos-de-recidiva-precoz-y-grave","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/recurrencia-de-la-infeccion-por-el-virus-de-la-hepatitis-c-vhc-tras-el-trasplante-hepatico-factores-predictivos-de-recidiva-precoz-y-grave\/","title":{"rendered":"Recurrencia de la infeccion por el virus de la hepatitis c (vhc) tras el trasplante hep\u00e1tico: factores predictivos de recidiva precoz y grave"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monserrat Garc\u00eda Retortillo <\/strong><\/h2>\n<p>La recurrencia de la infecci\u00f3n por el vhc se produce de forma universal tras el trasplante hep\u00e1tico (th), la hepatopat\u00eda secundaria a la recurrencia de la infecci\u00f3n tras el th evoluciona de forma m\u00e1s r\u00e1pida que en sujetos inmunocompetentes y condiciona aun peor supervivencia del injerto y del paciente.  * el estudio de la cin\u00e9tica viral del vhc durante el trasplante y en la fase inmediatamente posterior. A trav\u00e9s de este estudio se describi\u00f3 un descenso r\u00e1pido de la carga viral en la fase anhep\u00e1tica y en la de reperfusi\u00f3n debido a la falta de producci\u00f3n de viriones y de aclaramiento hep\u00e1tico. sin embargo, el genoma del vhc es detectable durante pr\u00e1cticamente todo el proceso y es a partir de estas part\u00edculas circulantes que se infecta el injerto. La replicaci\u00f3n viral se inicia a las pocas horas tras la reperfusi\u00f3n hep\u00e1tica como lo demuestra el incremento de la carga viral que se produce en los d\u00edas posteriores.  * eficacia y seguridad del tratamiento antiviral con interfer\u00f3n y ribavirina en pacientes cirr\u00f3ticos infectados por el vhc en lista de espera para trasplante hep\u00e1tico. Una de las estrategias propuestas para impedir la recidiva de la infecci\u00f3n tras el th es la erradicaci\u00f3n del vhc en la fase pre-th. La cirrosis avanzada constituye una contraindicaci\u00f3n para el tratamiento antiviral con interfer\u00f3n y ribavirina. Sin embargo, con una selecci\u00f3n adecuada de los pacientes y un seguimiento estrecho, la eficacia del tratamiento antiviral alcanz\u00f3 un 30% (negativizaci\u00f3n del arn-vhc). En un 20% de los pacientes del estudio se logr\u00f3 evitar la recidiva de la infecci\u00f3n tras el trasplante.  * recurrencia de la infecci\u00f3n por el vhc tras el  th en receptores de \u00f3rganos cadav\u00e9ricos versus receptores de donante vivo. A trav\u00e9s de este estudio prospectivo se demostr\u00f3 que la recurrencia de la infecci\u00f3n por el vhc en receptores de donante vivo es significativamente m\u00e1s grave que en los receptores de \u00f3rgano cadav\u00e9r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recurrencia de la infeccion por el virus de la hepatitis c (vhc) tras el trasplante hep\u00e1tico: factores predictivos de recidiva precoz y grave<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recurrencia de la infeccion por el virus de la hepatitis c (vhc) tras el trasplante hep\u00e1tico: factores predictivos de recidiva precoz y grave <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monserrat Garc\u00eda Retortillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Forns Bernhardt<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Esteban  mur <\/li>\n<li>Alberto Sanchez fueyo (vocal)<\/li>\n<li>v\u00edctor Vargas blasco (vocal)<\/li>\n<li>valent\u00edn Cuervas-mons mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monserrat Garc\u00eda Retortillo La recurrencia de la infecci\u00f3n por el vhc se produce de forma universal tras 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