{"id":74431,"date":"2005-09-06T00:00:00","date_gmt":"2005-09-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regeneracion-hepatica-regulacion-por-oxido-na%c2%adtrico-y-prostaglandinas\/"},"modified":"2005-09-06T00:00:00","modified_gmt":"2005-09-06T00:00:00","slug":"mecanismos-de-regeneracion-hepatica-regulacion-por-oxido-na%c2%adtrico-y-prostaglandinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-de-regeneracion-hepatica-regulacion-por-oxido-na%c2%adtrico-y-prostaglandinas\/","title":{"rendered":"Mecanismos de regeneraci\u00f3n hep\u00e1tica: regulaci\u00f3n por \u00f3xido n\u00edtrico y prostaglandinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Zeini Moreno <\/strong><\/h2>\n<p>Tras la resecci\u00f3n quir\u00fargica del 70% de la masa hep\u00e1tica mediante hepatectom\u00eda parcial (ph), el h\u00edgado desencadena una cascada de se\u00f1ales, que inician la recuperaci\u00f3n de una masa hep\u00e1tica adecuada a las demandas metab\u00f3licas del organismo. Entre las se\u00f1ales que participan en el proceso regenerativo se encuentran la expresi\u00f3n de las prote\u00ednas inducibles, nos-2 y cox-2. el \u00f3xido n\u00edtrico (no) y prostaglandinas (pgs) liberados por estas enzimas son enzimas con capaces de regular el proceso de generaci\u00f3n. En este trabajo, se ha analizado el papel del no y las pgs y su interrelaci\u00f3n en la regulaci\u00f3n del proceso regenerativo. Para ello, se analiz\u00f3 el papel de la liberaci\u00f3n de pgs en un modelo animal carente de nos-2 (nos-2 ko):  * la deficiencia simult\u00e1nea de no y pgs durante el proceso de regeneraci\u00f3n hep\u00e1tica tras la ph conlleva una apoptosis masiva de los hepatocitos e incapacidad proliferativa, que determinan una alta tasa de mortalidad de los animales tras la operaci\u00f3n. Este proceso es dependiente de la activaci\u00f3n de caspasas, puesto que el tratamiento en el inhibidor z-vad protegi\u00f3 a los animales del da\u00f1o hep\u00e1tico tras la ph. Aunque el no y las pgs no son imprescindibles para la recuperaci\u00f3n del tejido hep\u00e1tico, modulan el proceso regenerativo y el no coopera con metabolitos derivados de cox-2 para completar el proceso de recuperaci\u00f3n tras la ph.  puesto que el no ha mostrado ser hepatoprotector y protege a los hepatocitos de la apoptosis por diferentes da\u00f1os y del da\u00f1o mediado por citoquinas tras la ph, se analiz\u00f3 el efecto de la liberaci\u00f3n de no de manera previa a la ph usando un modelo animal transg\u00e9nico que expresaba nos-2 en h\u00edgado y un modelo de expresi\u00f3n de nos-2 en h\u00edgado por inyecci\u00f3n hidrodin\u00e1mica:  * la liberaci\u00f3n de no en h\u00edgado de manera previa a la ph causa un retraso en el proceso de regeneraci\u00f3n por la deficiente activaci\u00f3n de nf-kb y stat-3 y una menor liberaci\u00f3n de tnf-alfa e i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regeneraci\u00f3n hep\u00e1tica: regulaci\u00f3n por \u00f3xido n\u00edtrico y prostaglandinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regeneraci\u00f3n hep\u00e1tica: regulaci\u00f3n por \u00f3xido n\u00edtrico y prostaglandinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Zeini Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lisardo Bosc\u00e1 Gomar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Fern\u00e1ndez Garc\u00eda de castro <\/li>\n<li>paloma Mart\u00edn sanz (vocal)<\/li>\n<li>ramon Bartrons bach (vocal)<\/li>\n<li>Carlos Enrich bastos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Zeini Moreno Tras la resecci\u00f3n quir\u00fargica del 70% de la masa hep\u00e1tica mediante hepatectom\u00eda parcial (ph), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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