{"id":74465,"date":"2005-10-06T00:00:00","date_gmt":"2005-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-papel-del-transportador-de-aminoacidos-cationicos-cat-2-en-la-inflamacion-enfermedades-autoinmunes-e-inmunodeficiencias-primarias\/"},"modified":"2005-10-06T00:00:00","modified_gmt":"2005-10-06T00:00:00","slug":"el-papel-del-transportador-de-aminoacidos-cationicos-cat-2-en-la-inflamacion-enfermedades-autoinmunes-e-inmunodeficiencias-primarias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-papel-del-transportador-de-aminoacidos-cationicos-cat-2-en-la-inflamacion-enfermedades-autoinmunes-e-inmunodeficiencias-primarias\/","title":{"rendered":"El papel del transportador de amino\u00e1cidos cati\u00f3nicos (cat-2). en la inflamaci\u00f3n, enfermedades autoinmunes e inmunodeficiencias primarias"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez M\u00fa\u00f1oz Rosa M. <\/strong><\/h2>\n<p>Aunque el \u00f3xido n\u00edtrico (no) es un regulador principal de  la inflamaci\u00f3n, se ha puesto poca atenci\u00f3n en las mol\u00e9culas que regulan el no, como el transportador de amino\u00e1cidos cati\u00f3nicos 2 (cat-2). El objetivo ha sido identificar las citocinas inmunes moduladas en los macr\u00f3fagos deficientes de cat2 y estimulados con lps e ifn-gamma y examinar la respuesta inmune t dependiente de los ratones deficientes de cat2. Se estimularon ratones adultos controles, deficientes de inos y cat2 de ambos sexos de las cepas fvb\/n y c57b1\/6 con tioglicolato durante 72h. Los macr\u00f3fagos peritoneales (pm) se estimularon con 20 unidades\/ml de tfn-gamma durante 2h, y luego se a\u00f1adieron a los medios de cultivo 100 ng\/ml lps durante otras 17h. El rna total se asil\u00f3 y tras la transcripci\u00f3n inversa, los productos cdna se usaron para amplificaci\u00f3n por pcr a tiempo real de cat2, inos y varias citocinas. En toros estudios, se inyect\u00f3 intraperitoricalmente 100 g dnp-klh en adyuvante completo de reund a d\u00eda (d) 0 a los ratones de los tres genotipos de las dos cepas, y se volvi\u00f3 a estimular a d21 con 100 g dnp-klh en adyuvante completo de reund (\u00abbooster\u00bb) a los de la cepa c57b1\/6. El suero se recogi\u00f3 de d0, d7, d14, d21 y d28 en los ratones fvb\/n, y adem\u00e1s a d35 en los ratones c57b1\/6, determin\u00e1ndose los niveles de inmunoglobulinas s\u00e9ricas por elisa. se observ\u00f3 que la expresi\u00f3n de ifn-gamma, il-10 and il-4 estaba significativamente aumentada en los macr\u00f3fagos peritoneales (mp) deficientes de inos y cat2 comparada con los mp controles. La arginasa-i, y no la arginasa-ii estaba suprarregulada espec\u00edficamente en mpo  inos-\/-, sugiriendo que la activiad de la arginasa-i puede estar aumentada en ausencia del uso del sustrato por inos. En la cepa fvb\/n los niveles de igg2a e igg3 estaban disminuidos s\u00f3lo en los ratones deficientes de cat2; sin embargo, en la cepa c57\/b16 los niveles de igg2a estaban reducidos dr\u00e1sticamente en los ratones deficientes de i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El papel del transportador de amino\u00e1cidos cati\u00f3nicos (cat-2). en la inflamaci\u00f3n, enfermedades autoinmunes e inmunodeficiencias primarias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El papel del transportador de amino\u00e1cidos cati\u00f3nicos (cat-2). en la inflamaci\u00f3n, enfermedades autoinmunes e inmunodeficiencias primarias <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez M\u00fa\u00f1oz Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M. Angeles Mu\u00f1oz Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Nogales espert <\/li>\n<li>Juan  Antonio Le\u00f3n leal (vocal)<\/li>\n<li>salvador Resino garcia (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez M\u00fa\u00f1oz Rosa M. Aunque el \u00f3xido n\u00edtrico (no) es un regulador principal de la inflamaci\u00f3n, se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,139],"tags":[7781,76217,30047,131654,161303],"class_list":["post-74465","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-medicina-interna","tag-angel-nogales-espert","tag-juan-antonio-leon-leal","tag-m-angeles-munoz-fernandez","tag-salvador-resino-garcia","tag-sanchez-munoz-rosa-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74465"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74465\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}