{"id":74486,"date":"2005-10-06T00:00:00","date_gmt":"2005-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-variaciones-del-locus-genetico-de-la-apolipoprotea%c2%adna-c-ii-que-modulan-el-metabolismo-lipoproteico-y-la-respuesta-a-simvastatina-en-diabeticos-tipo-2-con-dislipemia\/"},"modified":"2005-10-06T00:00:00","modified_gmt":"2005-10-06T00:00:00","slug":"estudio-de-las-variaciones-del-locus-genetico-de-la-apolipoprotea%c2%adna-c-ii-que-modulan-el-metabolismo-lipoproteico-y-la-respuesta-a-simvastatina-en-diabeticos-tipo-2-con-dislipemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/estudio-de-las-variaciones-del-locus-genetico-de-la-apolipoprotea%c2%adna-c-ii-que-modulan-el-metabolismo-lipoproteico-y-la-respuesta-a-simvastatina-en-diabeticos-tipo-2-con-dislipemia\/","title":{"rendered":"Estudio de las variaciones del locus gen\u00e9tico de la apolipoprote\u00edna c-ii que modulan el metabolismo lipoproteico y la respuesta a simvastatina en diab\u00e9ticos tipo 2 con dislipemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Cordob\u00e9s L\u00f3pez <\/strong><\/h2>\n<p>Introducci\u00f3n     la diabetes tipo 2 representa una importante causa de morbi-mortalidad y de incapacidad permanente en los pa\u00edses desarrollados. La asociaci\u00f3n con otros factores de riesgo cardiovascular, sobre todo con hipertensi\u00f3n arterial, dislipemia y consumo de tabaco, incrementa la probabilidad de que el diab\u00e9tico presente un evento vascular. En la actualidad existe el consenso de realizar un tratamiento intensivo de dichos factores de riesgo cardiovascular en la poblaci\u00f3n diab\u00e9tica. el tratamiento hipolipemiante con inhibidores de la hmg-coa reductasa (estatinas) ha demostrado una disminuci\u00f3n de la mortalidad por los eventos cardiovasculares, pero existen pocos estudios que eval\u00faen la disminuci\u00f3n en la incidencia de patolog\u00eda cardiovascular en pacientes con diabetes tipo 2. La arterosclerosis es un proceso multifactorial, en el que intervienen tanto factores gen\u00e9ticos como ambientales: cada vez es m\u00e1s conocido la relaci\u00f3n entre determinados polimorfismos gen\u00e9ticos, la alteraci\u00f3n del metabolismo lipoproteico que condicionan y la modulaci\u00f3n del riesgo vascular que provocan. Uno de los polimorfismos m\u00e1s relacionados con la alteraci\u00f3n del metabolismo lipoproteico y la enfermedad cardiovascular es el gen de la apolipoprote\u00edna c-iii. No se conoce la posible influencia del polimorfismo gen\u00e9tico de la apo c-iii sobre la modulaci\u00f3n del metabolismo lipoproteico de la semivastatina en diab\u00e9ticos tipo 2 con dislipemia.  objetivos     evaluar el grado de control de los diferentes factores de riesgo cardiovascular en diab\u00e9ticos tipo 2 con dislipemia, despu\u00e9s de 6 meses de seguimiento, as\u00ed como determinar la respuesta terap\u00e9utica de simvastatina durante dicho per\u00edodo. Determinar la frecuencia y la influencia del polimorfismo de la apolipoprote\u00edna c-iii sobre el control metab\u00f3lico, su relaci\u00f3n con los factores de riesgo cardiovascular y con la presencia o no de macroangiopat\u00eda diab\u00e9tica.  dise\u00f1o     estudio quasiexperimental de int<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las variaciones del locus gen\u00e9tico de la apolipoprote\u00edna c-ii que modulan el metabolismo lipoproteico y la respuesta a simvastatina en diab\u00e9ticos tipo 2 con dislipemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las variaciones del locus gen\u00e9tico de la apolipoprote\u00edna c-ii que modulan el metabolismo lipoproteico y la respuesta a simvastatina en diab\u00e9ticos tipo 2 con dislipemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Cordob\u00e9s L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espino Montoro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li> L\u00f3pez chozas Jos\u00e9 Manuel (vocal)<\/li>\n<li>alipio Mangas rojas (vocal)<\/li>\n<li>Emilio M\u00e1rquez contrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Cordob\u00e9s L\u00f3pez Introducci\u00f3n la diabetes tipo 2 representa una importante causa de morbi-mortalidad y de incapacidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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