{"id":74511,"date":"2005-10-06T00:00:00","date_gmt":"2005-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/epidemiologia-molecular-de-los-genes-gstm1-gstt1-cyp1a1-y-mthfr-en-una-poblacion-de-pacientes\/"},"modified":"2005-10-06T00:00:00","modified_gmt":"2005-10-06T00:00:00","slug":"epidemiologia-molecular-de-los-genes-gstm1-gstt1-cyp1a1-y-mthfr-en-una-poblacion-de-pacientes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/epidemiologia-molecular-de-los-genes-gstm1-gstt1-cyp1a1-y-mthfr-en-una-poblacion-de-pacientes\/","title":{"rendered":"Epidemiolog\u00eda molecular de los genes gstm1, gstt1, cyp1a1 y mthfr en una poblaci\u00f3n de pacientes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andres Corno Caparros <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal (ccr) es una patolog\u00eda muy prevalente. Est\u00e1 asociado a factores gen\u00e9ticos, entre otros. La susceptibilidad individual al ccr puede ser debida a variaciones en la capacidad de activar y detoxificar end\u00f3genos y ex\u00f3genos y de reparar el da\u00f1o que estos provocan en el adn.  determinados polimorfismos en genes, pueden dar lugar a variaciones en las actividades detoxificadoras y reparadoras y as\u00ed aumentar el riesgo individual de padecerlo. Se estudian las frecuencias del polimorfismo nulo en los genes de detoxiviaci\u00f3n gstm1 y gstt1, las frecuencias del polimorfismo de corte msp i (t6235c) y lle462val 8c4889g) en el gen cyp1a1 de activaci\u00f3n metab\u00f3lica y las frecuencias del polimorfismo ala677val (c677t) en el gen mthfr del metabolismo de los folatos que participa en los mecanismos de s\u00edntesis, reparaci\u00f3n y metilaci\u00f3n del adn.  material y m\u00e9todo  estudio observacional de casos y controles incidentes, en cauc\u00e1sicos residentes en la misma \u00e1rea geogr\u00e1fica (vega baja alicante). Muestra de casos: 93 pacientes con diagn\u00f3stico confirmado de adenocarcinoma colorrectal (anatom\u00eda patol\u00f3gica) y controles, 117 pacientes hospitalarios con patolog\u00eda no neopl\u00e1sica (herniorrafias y colecistectom\u00edas).  se emple\u00f3 kit de qiagen para extraer y purificar el adn a partir de sangre total. Los polimorfismos nulos en gst;1 y gstt21 se analizaron mediante una m\u00faltiplex, siguiendo m\u00e9todo descrito por arand. Los polimorfismos en cyp1a1 se determinaron con el m\u00e9todo descrito por drakoulis 1994, por amplificaci\u00f3n y corte con msp i cyp1a1*2, y por aso cyp1a1*3 para el polimorfismo a4889g. el polimorfismo c677t en el gen mthfr por el m\u00e9todo de frosst por pcr y posterior digesti\u00f3n del amplificado con hinf.I.  se recogieron las variables: edad, g\u00e9nero, peso, talla, \u00edndice de masa corporal, h\u00e1bito de ingesta alcohol, h\u00e1bito tab\u00e1quico, localizaci\u00f3n tumoral, estadiaje de dukes y tipo histol\u00f3gico del tumor. En el an\u00e1lis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Epidemiolog\u00eda molecular de los genes gstm1, gstt1, cyp1a1 y mthfr en una poblaci\u00f3n de pacientes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Epidemiolog\u00eda molecular de los genes gstm1, gstt1, cyp1a1 y mthfr en una poblaci\u00f3n de pacientes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andres Corno Caparros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Compa\u00f1 Rosique<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Ferragut rodriguez <\/li>\n<li>eduardo Garcia granero ximenez (vocal)<\/li>\n<li>damian Garc\u00eda olmo (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andres Corno Caparros El c\u00e1ncer colorrectal (ccr) es una patolog\u00eda muy prevalente. Est\u00e1 asociado a factores gen\u00e9ticos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,11771,37169,347],"tags":[161377,33133,19295,12270,53895,3374],"class_list":["post-74511","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-genetica-clinica","category-miguel-hernandez-de-elche","category-oncologia-clinica","tag-andres-corno-caparros","tag-antonio-compan-rosique","tag-damian-garcia-olmo","tag-eduardo-garcia-granero-ximenez","tag-jesus-garcia-foncillas-lopez","tag-jose-antonio-ferragut-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74511"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74511\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}