{"id":74560,"date":"2018-03-09T23:19:36","date_gmt":"2018-03-09T23:19:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/consecuencias-de-la-inhibicion-de-la-ciclooxigenasa-2-en-modelos-experimentales-de-inflamacion-intestinal-mecanismos-moleculares-implicados\/"},"modified":"2018-03-09T23:19:36","modified_gmt":"2018-03-09T23:19:36","slug":"consecuencias-de-la-inhibicion-de-la-ciclooxigenasa-2-en-modelos-experimentales-de-inflamacion-intestinal-mecanismos-moleculares-implicados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/mecanismos-de-accion-de-los-farmacos\/consecuencias-de-la-inhibicion-de-la-ciclooxigenasa-2-en-modelos-experimentales-de-inflamacion-intestinal-mecanismos-moleculares-implicados\/","title":{"rendered":"Consecuencias de la inhibici\u00f3n de la ciclooxigenasa-2 en modelos experimentales de inflamaci\u00f3n intestinal: mecanismos moleculares implicados"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00edn Torrecillas Antonio  Ram\u00f3n <\/strong><\/h2>\n<p>Si bien las causas de eii permanecen y, en consecuencia, seguimos sin disponer de un tratamiento curativo, los \u00faltimos a\u00f1os han aportado importantes avances en el conocimiento de sus mecanismos patog\u00e9nicos. nosotros hemos valorado los efectos de un compuesto inhibidor selectivo de cox-2, rofecoxib, en comparaci\u00f3n con resveratrol, inhibidor selectivo de la cox-1, sobre mucosa col\u00f3nica sometida a colitis experimental (colitis aguda provocada por dss: colitis aguda y cr\u00f3nica inducida por tnbs). en los modelos utilizados estudiamos par\u00e1metros de respuesta inflamatoria e inmunol\u00f3gica, as\u00ed como algunos mecanismos de se\u00f1alizaci\u00f3n molecular (actividad mpo, niveles de citoquinas: il-1beta y de tnf-alfa, producci\u00f3n de prostanoides: pge2 y pgd2, expresi\u00f3n de ambas isoformas de la cox y de la prote\u00edna nf-kappa b, apoptosis o muerte celular programada). asimismo, examinaremos in vitro la producci\u00f3n de algunos mediadores inflamatorios en macr\u00f3fagos murinos de la l\u00ednea raw 264.7 estimulados con lps bacteriano. tanto rofecoxib como resveratrol, redujeron la severidad y la extensi\u00f3n del da\u00f1o macro y microsc\u00f3pico inducido por tnbs o dss, disminuyendo los par\u00e1metros bioqu\u00edmicos inflamatorios y la expresi\u00f3n de las prote\u00ednas cox-2 y nf-kappab. ambas mol\u00e9culas en ensayo tambi\u00e9n potenciaron la muerte celular provocada por el hapteno. finalmente las mol\u00e9culas en ensayo minimizaron los niveles de oxido n\u00edtrico y tnf-alfa por el lps en macr\u00f3fagos de la l\u00ednea raw.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Consecuencias de la inhibici\u00f3n de la ciclooxigenasa-2 en modelos experimentales de inflamaci\u00f3n intestinal: mecanismos moleculares implicados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Consecuencias de la inhibici\u00f3n de la ciclooxigenasa-2 en modelos experimentales de inflamaci\u00f3n intestinal: mecanismos moleculares implicados <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00edn Torrecillas Antonio  Ram\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/06\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Catalina Alarcon De La Lastra Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julio Cortijo giemeno <\/li>\n<li> Mart\u00edn calvo m. Luisa (vocal)<\/li>\n<li> Ayuso gonz\u00e1lez m. Jes\u00fas (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas Sanz ferrando (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00edn Torrecillas Antonio Ram\u00f3n Si bien las causas de eii permanecen y, en consecuencia, seguimos sin disponer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2445,483,10715],"tags":[10425,11295,161477,51460,161478,161476],"class_list":["post-74560","post","type-post","status-publish","format-standard","hentry","category-evaluacion-de-farmacos","category-mecanismos-de-accion-de-los-farmacos","category-sevilla","tag-ayuso-gonzalez-m-jesus","tag-catalina-alarcon-de-la-lastra-romero","tag-julio-cortijo-giemeno","tag-maria-jesus-sanz-ferrando","tag-martin-calvo-m-luisa","tag-martin-torrecillas-antonio-ramon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=74560"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/74560\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=74560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=74560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=74560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}